Brain cancer diagnosis and therapy with nanoplatforms

被引：237

作者：

Koo, Yong-Eun Lee

Reddy, G. Ramachandra

Bhojani, Mahaveer

Schneider, Randy

Philbert, Martin A.

Rehemtulla, Alnawaz

Ross, Brian D.

Kopelman, Raoul ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[2] Mol Therapeut Inc, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Environm Sci, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2006年 / 58卷 / 14期

关键词：

nanoparticles; blood-brain barrier; drug delivery; MRI; chemotherapy; photodynamic therapy; targeting;

D O I：

10.1016/j.addr.2006.09.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Treatment of brain cancer remains a challenge despite recent improvements in surgery and multimodal adjuvant therapy. Drug therapies of brain cancer have been particularly inefficient, due to the blood-brain barrier and the non-specificity of the potentially toxic drugs. The nanoparticle has emerged as a potential vector for brain delivery, able to overcome the problems of current strategies. Moreover, multi-functionality can be engineered into a single nanoplatform so that it can provide tumor-specific detection, treatment, and follow-up monitoring. Such multitasking is not possible with conventional technologies. This review describes recent advances in nanoparticle-based detection and therapy of brain cancer. The advantages of nanoparticle-based delivery and the types of nanoparticle systems under investigation are described, as well as their applications. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：1556 / 1577

页数：22

共 126 条

[11] UPTAKE OF SURFACTANT-COATED POLY(METHYL METHACRYLATE)-NANOPARTICLES BY BOVINE BRAIN MICROVESSEL ENDOTHELIAL-CELL MONOLAYERS [J].