New nucleoside analogues for the recognition of pyrimidine-purine inversion sites

被引:4
作者
Buchini, S [1 ]
Leumann, CJ [1 ]
机构
[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland
关键词
D O I
10.1081/NCN-120022835
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A new nucleoside designed to enhance triplex stability has been synthesised in 15 steps starting from sugar 2. This pathway contains the sugar derivative 9 which is a useful intermediate for the introduction of other natural and unnatural bases into the 2'-aminoethoxy nucleoside containing scaffold.
引用
收藏
页码:1199 / 1201
页数:3
相关论文
共 8 条
[1]  
Cuenoud B, 1998, ANGEW CHEM INT EDIT, V37, P1288, DOI 10.1002/(SICI)1521-3773(19980518)37:9<1288::AID-ANIE1288>3.0.CO
[2]  
2-U
[3]  
HELENE C, 1991, ANTI-CANCER DRUG DES, V6, P569
[4]   Synthesis of carbocyclic C-nucleosides containing nonnatural pyrimidine bases [J].
Hildbrand, S ;
Leumann, C ;
Scheffold, R .
HELVETICA CHIMICA ACTA, 1996, 79 (03) :702-709
[5]   DEGENERATIVE CHEMISTRY OF MALONDIALDEHYDE - STRUCTURE, STEREOCHEMISTRY, AND KINETICS OF FORMATION OF ENAMINALS FROM REACTION WITH AMINO-ACIDS [J].
NAIR, V ;
VIETTI, DE ;
COOPER, CS .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (11) :3030-3036
[6]  
Neidle S, 1997, ANTI-CANCER DRUG DES, V12, P433
[7]   Selective recognition of a C-G base-pair in the parallel DNA triple-helical binding motif [J].
Prévot-Halter, I ;
Leumann, CJ .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (18) :2657-2660
[8]   Synthesis of a novel bis-amino-modified thymidine monomer for use in DNA triplex stabilisation [J].
Sollogoub, M ;
Dominguez, B ;
Fox, KR ;
Brown, T .
CHEMICAL COMMUNICATIONS, 2000, (23) :2315-2316