Apoptosis: embedded in membranes

被引：59

作者：

Bogner, Christian ^{[1
]}

Leber, Brian ^{[1
,2
]}

Andrews, David W. ^{[1
]}

机构：

[1] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON L8N 3Z5, Canada

[2] McMaster Univ, Dept Med, Hamilton, ON L8N 3Z5, Canada

来源：

CURRENT OPINION IN CELL BIOLOGY | 2010年 / 22卷 / 06期

关键词：

BCL-2; FAMILY; BH3; DOMAIN; CELL-DEATH; MITOCHONDRIAL APOPTOSIS; BAX ACTIVATION; PROTEIN; BCL-X(L); PHOSPHORYLATION; DIMERIZATION; BINDING;

D O I：

10.1016/j.ceb.2010.08.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Many different signals for cell death converge on outer mitochondrial membrane permeabilization, a process controlled by the Bcl-2 family of proteins. Recent structural and biochemical analyses emphasize that key regulatory interactions between different classes of Bcl-2 family members occur at and in intracellular membranes, and insertion into membranes causes functionally important conformational changes in the proteins.

引用

页码：845 / 851

页数：7

共 55 条

[1] Quantitative analysis of pathways controlling extrinsic apoptosis in single cells [J].

Albeck, John G. ;

Burke, John M. ;

Aldridge, Bree B. ;

Zhang, Mingsheng ;

Lauffenburger, Douglas A. ;

Sorger, Peter K. .

MOLECULAR CELL, 2008, 30 (01) :11-25

[2] Rax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis [J].

Annis, MG ;

Dlugosz, PJ ;

Cruz-Aguado, JA ;

Penn, LZ ;

Leber, B ;

Andrews, DW .

EMBO JOURNAL, 2005, 24 (12) :2096-2103

[3] Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells [J].

Antonsson, B ;

Montessuit, S ;

Sanchez, B ;

Martinou, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (15) :11615-11623

[4] Substitutions of potentially phosphorylatable serine residues of Bax reveal how they may regulate its interaction with mitochondria [J].

Arokium, Hubert ;

Ouerfelli, Hakim ;

Velours, Gisele ;

Camougrand, Nadine ;

Vallette, Francois M. ;

Manon, Stephen .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (48) :35104-35112

[5] Bid: a Bax-like BH3 protein [J].

Billen, L. P. ;

Shamas-Din, A. ;

Andrews, D. W. .

ONCOGENE, 2008, 27 (Suppl 1) :S93-S104

[6] Bcl-XL inhibits membrane permeabilization by competing with Bax [J].

Billen, Lieven P. ;

Kokoski, Candis L. ;

Lovell, Jonathan F. ;

Leber, Brian ;

Andrews, David W. .

PLOS BIOLOGY, 2008, 6 (06) :1268-1280

[7] Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function [J].

Chen, L ;

Willis, SN ;

Wei, A ;

Smith, BJ ;

Fletcher, JI ;

Hinds, MG ;

Colman, PM ;

Day, CL ;

Adams, JM ;

Huang, DCS .

MOLECULAR CELL, 2005, 17 (03) :393-403

[8] Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins [J].

Chipuk, Jerry E. ;

Fisher, John C. ;

Dillon, Christopher P. ;

Kriwacki, Richard W. ;

Kuwana, Tomomi ;

Green, Douglas R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (51) :20327-20332

[9] Solution structure of BID, an intracellular amplifier of apoptotic signaling [J].

Chou, JJ ;

Li, HL ;

Salvesen, GS ;

Yuan, JY ;

Wagner, G .

CELL, 1999, 96 (05) :615-624

[10] Apoptosis and cancer: the genesis of a research field [J].

Cotter, Thomas G. .

NATURE REVIEWS CANCER, 2009, 9 (07) :501-507

← 1 2 3 4 5 6 →