MicroRNAs in skin and wound healing

被引：108

作者：

Banerjee, Jaideep ^{[1
]}

Chan, Yuk Cheung ^{[1
]}

Sen, Chandan K. ^{[1
]}

机构：

[1] Ohio State Univ, Med Ctr, Davis Heart & Lung Res Inst, Dept Surg, Columbus, OH 43210 USA

来源：

PHYSIOLOGICAL GENOMICS | 2011年 / 43卷 / 10期

关键词：

miRNA therapy; hypoxia; REPRESSES CELL-PROLIFERATION; TUMOR-SUPPRESSOR GENE; E-CADHERIN; GROWTH-FACTOR; MIR-200; FAMILY; MESENCHYMAL TRANSITION; CANCER-CELLS; P53; HOMOLOG; STEM-CELLS; EXPRESSION;

D O I：

10.1152/physiolgenomics.00157.2010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Banerjee J, Chan YC, Sen CK. MicroRNAs in skin and wound healing. Physiol Genomics 43: 543-556, 2011. First published October 19, 2010; doi:10.1152/physiolgenomics.00157.2010.-MicroRNAs (miRNAs) are small endogenous RNA molecules similar to 22 nt in length. miRNAs are capable of posttranscriptional gene regulation by binding to their target messenger RNAs (mRNAs), leading to mRNA degradation or suppression of translation. miRNAs have recently been shown to play pivotal roles in skin development and are linked to various skin pathologies, cancer, and wound healing. This review focuses on the role of miRNAs in cutaneous biology, the various methods of miRNA modulation, and the therapeutic opportunities in treatment of skin diseases and wound healing.

引用

收藏

页码：543 / 556

页数：14

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