PGC1α Confers Specificity-Metabolic Stress and p53-Dependent Transcription

被引：11

作者：

Cioce, Mario ^{[1
]}

Blandino, Giovanni ^{[1
]}

机构：

[1] Italian Natl Canc Inst Regina Elena, Translat Oncogenom Unit, I-00144 Rome, Italy

来源：

MOLECULAR CELL | 2011年 / 44卷 / 04期

关键词：

P53;

D O I：

10.1016/j.molcel.2011.11.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

引用

收藏

页码：515 / 516

页数：2

相关论文

共 11 条

[1]

Integrated genomic analyses of ovarian carcinoma [J].

Bell, D. ;

Berchuck, A. ;

Birrer, M. ;

Chien, J. ;

Cramer, D. W. ;

Dao, F. ;

Dhir, R. ;

DiSaia, P. ;

Gabra, H. ;

Glenn, P. ;

Godwin, A. K. ;

Gross, J. ;

Hartmann, L. ;

Huang, M. ;

Huntsman, D. G. ;

Iacocca, M. ;

Imielinski, M. ;

Kalloger, S. ;

Karlan, B. Y. ;

Levine, D. A. ;

Mills, G. B. ;

Morrison, C. ;

Mutch, D. ;

Olvera, N. ;

Orsulic, S. ;

Park, K. ;

Petrelli, N. ;

Rabeno, B. ;

Rader, J. S. ;

Sikic, B. I. ;

Smith-McCune, K. ;

Sood, A. K. ;

Bowtell, D. ;

Penny, R. ;

Testa, J. R. ;

Chang, K. ;

Dinh, H. H. ;

Drummond, J. A. ;

Fowler, G. ;

Gunaratne, P. ;

Hawes, A. C. ;

Kovar, C. L. ;

Lewis, L. R. ;

Morgan, M. B. ;

Newsham, I. F. ;

Santibanez, J. ;

Reid, J. G. ;

Trevino, L. R. ;

Wu, Y. -Q. ;

Wang, M. .

NATURE, 2011, 474 (7353) :609-615

[2]

Reactivation of p53: from peptides to small molecules [J].

Brown, Christopher J. ;

Cheok, Chit F. ;

Verma, Chandra S. ;

Lane, David P. .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2011, 32 (01) :53-62

[3]

Metabolic utilization of exogenous pyruvate by mutant p53 (R175H) human melanoma cells promotes survival under glucose depletion [J].

Chavez-Perez, Valery A. ;

Strasberg-Rieber, Mary ;

Rieber, Manuel .

CANCER BIOLOGY & THERAPY, 2011, 12 (07) :647-656

[4]

p53 Regulation of Metabolic Pathways [J].

Gottlieb, Eyal ;

Vousden, Karen H. .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2010, 2 (04) :a001040

[5]

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α [J].

Jaeger, Sibylle ;

Handschin, Christoph ;

St.-Pierre, Julie ;

Spiegelman, Bruce M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (29) :12017-12022

[6]

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint [J].

Jones, RG ;

Plas, DR ;

Kubek, S ;

Buzzai, M ;

Mu, J ;

Xu, Y ;

Birnbaum, MJ ;

Thompson, CB .

MOLECULAR CELL, 2005, 18 (03) :283-293

[7]

The first 30 years of p53: growing ever more complex [J].

Levine, Arnold J. ;

Oren, Moshe .

NATURE REVIEWS CANCER, 2009, 9 (10) :749-758

[8]

Metformin, diet and breast cancer An avenue for chemoprevention [J].

Muti, Paola ;

Berrino, Franco ;

Krogh, Vittorio ;

Villarini, Anna ;

Barba, Maddalena ;

Strano, Sabrina ;

Blandino, Giovanni .

CELL CYCLE, 2009, 8 (16) :2661-2661

[9]

PGC-1α, a Key Modulator of p53, Promotes Cell Survival upon Metabolic Stress [J].

Sen, Nirmalya ;

Satija, Yatendra Kumar ;

Das, Sanjeev .

MOLECULAR CELL, 2011, 44 (04) :621-634

[10]

The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA damage [J].

Strano, S ;

Monti, O ;

Pediconi, N ;

Baccarini, A ;

Fontemaggi, G ;

Lapi, E ;

Mantovani, F ;

Damalas, A ;

Citro, G ;

Sacchi, A ;

Del Sal, G ;

Levrero, M ;

Blandino, G .

MOLECULAR CELL, 2005, 18 (04) :447-459