Antibodies against GluR3 peptides are not specific for Rasmussen's encephalitis but are also present in epilepsy patients with severe, early onset disease and intractable seizures

被引:116
作者
Mantegazza, R
Bernasconi, P
Baggi, F
Spreafico, R
Ragona, F
Antozzi, C
Bernardi, G
Granata, T
机构
[1] Ist Nazl Neurol Carlo Besta, Immunol & Muscular Pathol Unit, I-20133 Milan, Italy
[2] Ist Nazl Neurol Carlo Besta, Dept Expt Neurophysiol & Epileptol, I-20133 Milan, Italy
[3] Ist Nazl Neurol Carlo Besta, Dept Child Neurol, I-20133 Milan, Italy
[4] Ist Nazl Neurol Carlo Besta, Dept Neuromuscular Dis, I-20133 Milan, Italy
[5] Ist Nazl Neurol Carlo Besta, Cent Lab, I-20133 Milan, Italy
关键词
Rasmussen's encephalitis; antibodies against GluR3 peptide; epilepsy; autoimmune reactivity; ELISA;
D O I
10.1016/S0165-5728(02)00261-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Rasmussen's encephalitis (RE) is a rare condition characterized by drug-resistant seizures, recurrent status epilepticus and progressive lateralized neurological deterioration. There is evidence of autoimmune involvement in the pathogenesis. We investigated the presence of anti-GluR3 antibodies against peptides A and B in patients with RE (n = 11), partial and generalized epilepsy (n = 85) and other neurological diseases (n=30). The antibodies were specific for epilepsy and are thus not a marker of RE, while particularly high antibody titers characterized a subgroup of non-RE patients with "catastrophic" epilepsy, Antibodies against GluR3B peptide were significantly associated with frequent seizures compared to occasional or drug-controlled seizures. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:179 / 185
页数:7
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