What Sets Bacillus anthracis Apart from Other Bacillus Species?

被引：171

作者：

Kolsto, Anne-Brit ^{[1
]}

Tourasse, Nicolas J.

Okstad, Ole Andreas

机构：

[1] Univ Oslo, Sch Pharm, Lab Microbial Dynam, N-0316 Oslo, Norway

来源：

ANNUAL REVIEW OF MICROBIOLOGY | 2009年 / 63卷

关键词：

Bacillus cereus group; classification; phylogeny; plasmids; clonal lineage; SEQUENCE TYPING ANALYSIS; PLCR VIRULENCE REGULON; CEREUS-GROUP; POPULATION-STRUCTURE; GENOME SEQUENCE; TOXIN GENES; REPEAT ELEMENT; PXO1; PLASMID; THURINGIENSIS; IDENTIFICATION;

D O I：

10.1146/annurev.micro.091208.073255

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bacillus anthracis is the cause of anthrax, and two large plasmids are essential for toxicity: pXO1, which contains the toxin genes, and pXO2, which encodes a capsule. B. anthracis forms a highly monomorphic lineage within the B. cereus group, but strains of Bacillus thuringiensis and B. cereus exist that ire genetically closely related to the B. anthracis cluster. During the past five years B. cereus strains that contain the pXO1 virulence plasmid were discovered, and strains with both pXO1 and pXO2 have been isolated from great apes in Africa. Therefore, the presence of pXO1 and pXO2 no longer principally separates B. anthracis from other Bacilli. The B. anthracis lineage carries a specific mutation in the global regulator PlcR, which controls the transcription of secreted virulence factors in B. cereus and B. thuringiensis. Coevolution of the B. anthracis chromosome with its plasmids may be the basis for the successful development and uniqueness of the B. anthracis lineage.

引用

页码：451 / 476

页数：26

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