Amino acid transport System A resembles System N in sequence but differs in mechanism

被引：158

作者：

Reimer, RJ

Chaudhry, FA

Grays, AT

Edwards, RH

机构：

[1] Univ Calif San Francisco, Sch Med, Dept Neurol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Sch Med, Dept Physiol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Sch Med, Dept Anesthesia, Grad Program Neurosci, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Sch Med, Grad Program Cell Biol, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Sch Med, Grad Program Biomed Sci, San Francisco, CA 94143 USA

[6] Univ Oslo, Inst Basic Med Sci, Dept Anat, N-0317 Oslo, Norway

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 14期

关键词：

D O I：

10.1073/pnas.140152797

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Classical amino acid transport System A accounts for most of the Na+-dependent neutral amino acid uptake by mammalian cells. System A has also provided a paradigm for short- and long-term regulation by physiological stimuli. We now report the isolation of a cDNA encoding System A that shows close similarity to the recently identified System N transporter (SN1). The System A transporter (SA1) and SN1 share many functional characteristics, including a marked sensitivity to low pH, but, unlike SN1, SA1 does not mediate proton exchange. Transport mediated by SA1 is also electrogenic. Amino acid transport Systems A and N thus appear closely related in function as well as structure, but exhibit important differences in ionic coupling.

引用

页码：7715 / 7720

页数：6

共 44 条

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