LIGHT-HVEM signaling and the regulation of T cell-mediated immunity

被引：108

作者：

Granger, SW ^{[1
]}

Rickert, S ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, Div Mol Immunol, San Diego, CA 92121 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2003年 / 14卷 / 3-4期

关键词：

TNF; LIGHT; HVEM; co-stimulation; GVHD;

D O I：

10.1016/S1359-6101(03)00031-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

LIGHT is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). This review will present a summary of recent advances made regarding the immunobiology of the LIGHT-HVEM and LTbetaR systems. LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes. In contrast to LTalphabeta, LIGHT plays a minimal role in lymphoid tissue development, yet some evidence indicates a role in negative selection in the thymus. These results provide an encouraging profile for the LIGHT-HVEM-LTbetaR axis as a potential target for controlling cellular immune reactions. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：289 / 296

页数：8

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