Studies on the genotoxicity of tamoxifen citrate in mouse bone marrow cells

被引：15

作者：

Vijayalaxmi, KK

Rai, SP

机构：

[1] Dept. of Studies in Applied Zoology, Mangalore University, Mangalagangotri - 574 199, D.K.

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY | 1996年 / 368卷 / 02期

关键词：

tamoxifen citrate; chromosomal aberration; bone marrow cell; micronucleus;

D O I：

10.1016/0165-1218(95)00101-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genotoxic effects of tamoxifen citrate, an anti-oestrogenic drug, were studied using mouse bone marrow chromosome aberration assay (CA) and micronucleus (MN) test. The dose and time yield effects of the drug were investigated after repeated administration of various doses of the drug for 10 days. The doses used were, 0.1, 0.2, 0.4 and 0.8 mg/kg/day. Bone marrow preparations were made at 24, 48, 72 and 96 h after the last administration. The anticancer drug cyclophosphamide (CP) at a dose of 100 mg/kg was used as positive control. A statistically significant chromosomal aberration and MN induced by tamoxifen revealed its clastogenic potency.

引用

页码：109 / 114

页数：6

共 30 条

[21] A MECHANISTIC HYPOTHESIS FOR DNA ADDUCT FORMATION BY TAMOXIFEN FOLLOWING HEPATIC OXIDATIVE-METABOLISM [J].