Telomere biology in healthy aging and disease

被引：192

作者：

Oeseburg, Hisko ^{[1
]}

de Boer, Rudolf A. ^{[1
]}

van Gilst, Wiek H. ^{[1
]}

van der Harst, Pim ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9700 RB Groningen, Netherlands

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2010年 / 459卷 / 02期

关键词：

Aging; Tumor; Heart; Apoptosis; Cell death; IMPROVES CARDIAC-FUNCTION; HEMATOPOIETIC STEM-CELLS; C-REACTIVE PROTEIN; ANGIOTENSIN-II; HEART-FAILURE; CARDIOVASCULAR-DISEASE; TERMINAL TRANSFERASE; CELLULAR SENESCENCE; CIGARETTE-SMOKING; OXIDATIVE STRESS;

D O I：

10.1007/s00424-009-0728-1

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

Aging is a biological process that affects most cells, organisms and species. Telomeres have been postulated as a universal biological clock that shortens in parallel with aging in cells. Telomeres are located at the end of the chromosomes and consist of an evolutionary conserved repetitive nucleotide sequence ranging in length from a few hundred base pairs in yeast till several kilo base pairs in vertebrates. Telomeres associate with shelterin proteins and form a complex protecting the chromosomal deoxyribonucleic acid (DNA) from recognition by the DNA damage-repair system. Due to the "end-replication problem" telomeres shorten with each mitotic cycle resulting in cumulative telomere attrition during aging. When telomeres reach a critical length the cell will not further undergo cell divisions and become senescent or otherwise dysfunctional. Telomere shortening has not only been linked to aging but also to several age associated diseases, including tumorigenesis, coronary artery disease, and heart failure. In the current review, we will discuss the role of telomere biology in relation to aging and aging associated diseases.

引用

页码：259 / 268

页数：10

共 105 条

[1]

Telomere shortening occurs in Asian Indian Type 2 diabetic patients [J].

Adaikalakoteswari, A ;

Balasubramanyam, M ;

Mohan, V .

DIABETIC MEDICINE, 2005, 22 (09) :1151-1156

[2]

The pathophysiology of cigarette C-V smoking and cardiovascular disease - An update [J].

Ambrose, JA ;

Barua, RS .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (10) :1731-1737

[3]

Clinical impact of vasomotor function assessment and the role of ACE-inhibitors and statins [J].

Asselbergs, FW ;

van der Harst, P ;

Jessurun, GAJ ;

Tio, RA ;

van Gilst, WH .

VASCULAR PHARMACOLOGY, 2005, 42 (03) :125-140

[4]

Telomeres and aging [J].

Aubert, Geraldine ;

Lansdorp, Peter M. .

PHYSIOLOGICAL REVIEWS, 2008, 88 (02) :557-579

[5]

Extensive allelic variation and ultrashort telomeres in senescent human cells [J].

Baird, DM ;

Rowson, J ;

Wynford-Thomas, D ;

Kipling, D .

NATURE GENETICS, 2003, 33 (02) :203-207

[6]

TANDEMLY REPEATED SEQUENCE AT TERMINI OF EXTRACHROMOSOMAL RIBOSOMAL-RNA GENES IN TETRAHYMENA [J].

BLACKBURN, EH ;

GALL, JG .

JOURNAL OF MOLECULAR BIOLOGY, 1978, 120 (01) :33-53

[7]

Telomeres and human disease: Ageing, cancer and beyond [J].

Blasco, MA .

NATURE REVIEWS GENETICS, 2005, 6 (08) :611-622

[8]

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA [J].

Blasco, MA ;

Lee, HW ;

Hande, MP ;

Samper, E ;

Lansdorp, PM ;

DePinho, RA ;

Greider, CW .

CELL, 1997, 91 (01) :25-34

[9]

White cell telomere length and risk of premature myocardial infarction [J].

Brouilette, S ;

Singh, RK ;

Thompson, JR ;

Goodall, AH ;

Samani, NJ .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (05) :842-846

[10]

Telomere length is shorter in healthy offspring of subjects with coronary artery disease: support for the telomere hypothesis [J].

Brouilette, S. W. ;

Whittaker, A. ;

Stevens, S. E. ;

van der Harst, P. ;

Goodall, A. H. ;

Samani, N. J. .

HEART, 2008, 94 (04) :422-425

← 1 2 3 4 5 6 7 8 9 10 →