B-mode and color Doppler ultrasound imaging for localization of microelectrode in monkey brain

被引:20
作者
Tokuno, H [1 ]
Hatanaka, N [1 ]
Takada, M [1 ]
Nambu, A [1 ]
机构
[1] Tokyo Metropolitan Inst Neurosci, Tokyo 1838526, Japan
关键词
ultrasonography; B-mode scan; color Doppler imaging; extracellular recording; microelectrode; monkey;
D O I
10.1016/S0168-0102(99)00133-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Using alert monkeys, we attempted ultrasound imaging after partial craniotomy to localize a metal microelectrode in the brain. B-mode ultrasonography provided images of sulcus and gyrus patterns of the cerebral cortex, and locations of the ventricles and subarachnoid cisterns. As the microelectrode proceeded in the brain, the position of the microelectrode was clearly identified. Electrolytic microlesions generated by delivering direct currents via the microelectrode could also be detected. Color Doppler imaging of blood vessels of the brain was helpful to demarcate deep brain structures and to avoid accidental injury of the blood vessels by the microelectrode. The ultrasonography will make it possible to place recording microelectrodes or injection needles accurately in target regions of the brain in physiological, anatomical or behavioral experiments. (C) 2000 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
引用
收藏
页码:335 / 338
页数:4
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