Herpes Simplex Encephalitis during Treatment with Tumor Necrosis Factor-α Inhibitors

被引：57

作者：

Bradford, Russell D. ^{[1
]}

Pettit, April C. ^{[4
]}

Wright, Patty W. ^{[4
]}

Mulligan, Mark J. ^{[6
]}

Moreland, Larry W. ^{[7
]}

McLain, David A.

Gnann, John W. ^{[1
,2
,3
]}

Bloch, Karen C. ^{[4
,5
]}

机构：

[1] Univ Alabama, Dept Pediat, Div Infect Dis, Birmingham, AL 35233 USA

[2] Univ Alabama, Dept Med, Div Infect Dis, Birmingham, AL 35233 USA

[3] Birmingham VA Med Ctr, Birmingham, AL USA

[4] Vanderbilt Univ, Sch Med, Div Infect Dis, Dept Med, Nashville, TN 37212 USA

[5] Vanderbilt Univ, Sch Med, Dept Prevent Med, Nashville, TN 37212 USA

[6] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA USA

[7] Univ Pittsburgh, Dept Med, Div Clin Immunol & Rheumatol, Pittsburgh, PA 15260 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2009年 / 49卷 / 06期

基金：

美国国家卫生研究院;

关键词：

POLYMERASE-CHAIN-REACTION; RHEUMATOID-ARTHRITIS; CEREBROSPINAL-FLUID; VIRUS ENCEPHALITIS; INFECTIONS; MANAGEMENT; DIAGNOSIS; THERAPY; RISK;

D O I：

10.1086/605498

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

We report 3 cases of herpes simplex virus encephalitis in patients receiving tumor necrosis factor-alpha (TNF-alpha) inhibitors for rheumatologic disorders. Although TNF-alpha inhibitors have been reported to increase the risk of other infectious diseases, to our knowledge, an association between anti-TNF-alpha drugs and herpes simplex virus encephalitis has not been previously described.

引用

页码：924 / 927

页数：4

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