共 48 条
Differences in expression of toll-like receptors and their reactivities in dendritic cells in BALB/c and C57BL/6 mice
被引:126
作者:

Liu, T
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机构: Kyushu Univ, Div Host Def, Res Ctr Prevent Infect Dis, Med Inst Bioregulat, Fukuoka 8128585, Japan

Matsuguchi, T
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机构: Kyushu Univ, Div Host Def, Res Ctr Prevent Infect Dis, Med Inst Bioregulat, Fukuoka 8128585, Japan

Tsuboi, N
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h-index: 0
机构: Kyushu Univ, Div Host Def, Res Ctr Prevent Infect Dis, Med Inst Bioregulat, Fukuoka 8128585, Japan

Yajima, T
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机构: Kyushu Univ, Div Host Def, Res Ctr Prevent Infect Dis, Med Inst Bioregulat, Fukuoka 8128585, Japan

Yoshikai, Y
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h-index: 0
机构:
Kyushu Univ, Div Host Def, Res Ctr Prevent Infect Dis, Med Inst Bioregulat, Fukuoka 8128585, Japan Kyushu Univ, Div Host Def, Res Ctr Prevent Infect Dis, Med Inst Bioregulat, Fukuoka 8128585, Japan
机构:
[1] Kyushu Univ, Div Host Def, Res Ctr Prevent Infect Dis, Med Inst Bioregulat, Fukuoka 8128585, Japan
[2] Nagoya Univ, Host Def Lab, Dis Mechanism & Control Res Inst, Grad Sch Med, Nagoya, Aichi 4668550, Japan
关键词:
D O I:
10.1128/IAI.70.12.6638-6645.2002
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
We have previously reported that differences in early production of interleukin 12 (IL-12) by dendritic cells (DC) underlies the difference between the susceptibilities to Listeria monocytogenes of C57BL/6 and BALB/c mice. To elucidate mechanisms for the different abilities of DC to produce cytokine in C57BL/6 and BALB/c mice, we examined Toll-like receptor (TLR) expression by DC and their responses in vitro to known microbial ligands for TLRs. We found that DC isolated from the spleens of naive C57BL/6 mice preferentially expressed TLR9 mRNA, whereas DC from naive BALB/c mice strongly expressed TLR2, -4, -5, and -6 mRNAs. C57BL/6 DC produced a higher level of IL-12p40 in response to the ligands for TLR4 (lipopolysaccharide), TLR2 (lipoprotein), and TLR9 (CpG), whereas BALB/c DC responded to these ligands by producing a larger amount of monocyte chemoattractant protein 1. C57BL/6 DC expressed higher levels of CD40 and Stat4 than BALB/c DC did, suggesting that naive C57BL/6 mice contained more-mature subsets of DC than naive BALB/c mice. Differences in reactivities of DC to microbial molecules through TLRs may be associated with susceptibility and resistance to Listeria infection in BALB/c and C57BL/6 mice.
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页码:6638 / 6645
页数:8
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