Hypolipidemic Effects of Ethanol Extracts of Citrus depressa and Annona atemoya, Typical Plant Foodstuffs in Okinawa, Japan on KKAy Mice Fed with Moderately High Fat Diet

被引：5

作者：

Beppu, Fumiaki ^{[1
]}

Niwano, Yoshimi ^{[1
]}

Kyan, Rika ^{[2
]}

Yasura, Kazumasa ^{[3
]}

Tamaki, Minori ^{[3
]}

Nishino, Michinori ^{[4
]}

Midorikawa, Yoshiyuki ^{[4
]}

Hamada, Hiroki ^{[2
]}

机构：

[1] Saito Biotechnol Incubator, Sunny Hlth Holdings Co Ltd, Res Ctr Funct Food Mat, Osaka 5670085, Japan

[2] Okayama Univ Sci, Dept Life Sci, Okayama 7000005, Japan

[3] Biremo Okinawa Co Ltd, Okinawa 9010302, Japan

[4] Nansei Shoto Ind Advancement Ctr, Okinawa 9000015, Japan

来源：

FOOD SCIENCE AND TECHNOLOGY RESEARCH | 2009年 / 15卷 / 05期

关键词：

Okinawan fruits; Citrus depressa; Annona atemoya; hypolipidemic activity; ADIPOSE-TISSUES; FUCOXANTHIN; EXPRESSION; LONGEVITY; PROFILE;

D O I：

10.3136/fstr.15.553

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Okinawa is an isolated island prefecture of Japan and is known for the longest life expectancy and low disability rate. We therefore focused on the effects of traditional Okinawan fruits Citrus depressa and Annona atemoya consumed by the Okinawan population. Repeated oral administration of ethanol extracts of C depressa and A. atemoya potently lowered the plasma triglyceride (TG) concentrations of KKAy mice fed a moderately high fat diet for 4 weeks. Since diet intake and body weight were not reduced following administration of the C. depressa extract, TG absorption from the intestine is unlikely inhibited by this extract. Our previous study showed that the A. atemoya extract possesses a potent inhibitory effect on adipogenesis of 3T3 adipocytes. Thus, reduced fatty acid mobilization from the adipose tissue by the A. atemoya extract may result in the reduction in TG synthesis in the liver. This is the first report on the hypolipidemic effects of C. depressa and A. atemoya. Their extracts of these fruits are expected to be useful for the prevention of life style-related diseases.

引用

页码：553 / 556

页数：4

共 10 条

[1] LIPOPROTEIN PROFILE CHARACTERIZATION OF THE KKA(Y) MOUSE, A RODENT MODEL OF TYPE-II DIABETES, BEFORE AND AFTER TREATMENT WITH THE INSULIN-SENSITIZING AGENT PIOGLITAZONE [J].

CASTLE, CK ;

COLCA, JR ;

MELCHIOR, GW .

ARTERIOSCLEROSIS AND THROMBOSIS, 1993, 13 (02) :302-309

[2] The effects of β3-adrenoceptor agonist CL-316,243 on adiponectin, adiponectin receptors and tumor necrosis factor-α expressions in adipose tissues of obese diabetic KKAy mice [J].

Fu, Ling ;

Isobe, Kazumasa ;

Zeng, Qin ;

Suzukawa, Kazumi ;

Takekoshi, Kazuhiro ;

Kawakami, Yasushi .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 584 (01) :202-206

[3] Effect of niacin on lipoproteins and atherosclerosis [J].

Ganji, Sbobba H. ;

Zhang, Lin-Hua ;

Kamanna, Vaijinath S. ;

Kasbyap, Moti L. .

FUTURE LIPIDOLOGY, 2006, 1 (05) :549-557

[4] Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues [J].

Maeda, H ;

Hosokawa, M ;

Sashima, T ;

Funayama, K ;

Miyashita, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 332 (02) :392-397

[5] Extensive Screening for Plant Foodstuffs in Okinawa, Japan with Anti-Obese Activity on Adipocytes In Vitro [J].

Niwano, Yoshimi ;

Beppu, Fumiaki ;

Shimada, Taichi ;

Kyan, Rika ;

Yasura, Kazumasa ;

Tamaki, Minori ;

Nishino, Michinori ;

Midorikawa, Yoshiyuki ;

Hamada, Hiroki .

PLANT FOODS FOR HUMAN NUTRITION, 2009, 64 (01) :6-10

[6] Increased insulin sensitivity and changes in the expression profile of key insulin regulatory genes and beta cell transcription factors in diabetic KKAy-mice after feeding with a soy bean protein rich diet high in isoflavone content [J].

Nordentoft, I. ;

Jeppesen, P. B. ;

Hong, J. ;

Abudula, R. ;

Hermansen, K. .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (12) :4377-4385

[7]

SANTOS RD, 2005, ARQ BRAS CARDIOL S, V5, P17

[8]

Sho H, 2001, ASIA PAC J CLIN NUTR, V10, P159, DOI 10.1046/j.1440-6047.2001.00235.x

[9] Sleep health and lifestyle of elderly people in Ogimi, a village of longevity [J].

Taira, K ;

Tanaka, H ;

Arakawa, M ;

Nagahama, N ;

Uza, M ;

Shirakawa, S .

PSYCHIATRY AND CLINICAL NEUROSCIENCES, 2002, 56 (03) :243-244

[10] Fucoxanthin and fucoxanthinol enhance the amount of docosahexaenoic acid in the liver of KKAy obese/diabetic mice [J].

Tsukui, Takayuki ;

Konno, Kensuke ;

Hosokawa, Masashi ;

Maeda, Hayato ;

Sashima, Tokutake ;

Miyashita, Kazuo .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 55 (13) :5025-5029

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