PcrV immunization enhances survival of burned Pseudomonas aeruginosa-infected mice

被引：75

作者：

Holder, IA

Neely, AN

Frank, DW

机构：

[1] Shriners Hosp Children, Dept Microbiol, Cincinnati, OH 45229 USA

[2] Med Coll Wisconsin, Milwaukee, WI 53226 USA

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 09期

关键词：

D O I：

10.1128/IAI.69.9.5908-5910.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Burned Pseudomonas aeruginosa-infected mice immunized against PcrV, a type III virulence system translocating protein, showed significantly enhanced survival compared to controls. Survival was non-O serotype specific and correlated with a reduced systemic microbial load. Infection with a high-level toxin A-producing strain required supplemental antitoxin treatment to enhance survival.

引用

收藏

页码：5908 / 5910

页数：3

相关论文

共 14 条

[1] The Yersinia deadly kiss [J].

Cornelis, GR .

JOURNAL OF BACTERIOLOGY, 1998, 180 (21) :5495-5504

[2] PROTECTION AGAINST PSEUDOMONAS-AERUGINOSA INFECTION IN A MURINE BURN WOUND SEPSIS MODEL BY PASSIVE TRANSFER OF ANTITOXIN-A, ANTIELASTASE, AND ANTILIPOPOLYSACCHARIDE [J].

CRYZ, SJ ;

FURER, E ;

GERMANIER, R .

INFECTION AND IMMUNITY, 1983, 39 (03) :1072-1079

[3] The exoenzyme S regulon of Pseudomonas aeruginosa [J].

Frank, DW .

MOLECULAR MICROBIOLOGY, 1997, 26 (04) :621-629

[4]

Holder I A, 1989, J Burn Care Rehabil, V10, P131, DOI 10.1097/00004630-198903000-00006

[5] Type III secretion/intoxication system important in virulence of Pseudomonas aeruginosa infections in burns [J].

Holder, IA ;

Neely, AN ;

Frank, DW .

BURNS, 2001, 27 (02) :129-130

[6] Type III protein secretion systems in bacterial pathogens of animals and plants [J].

Hueck, CJ .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 1998, 62 (02) :379-+

[7] Type III secretion systems: Machines to deliver bacterial proteins into eukaryotic cells? [J].

Lee, CA .

TRENDS IN MICROBIOLOGY, 1997, 5 (04) :148-156

[8] A murine model with aspects of clinical relevance for the study of antibiotic-induced endotoxin release in septic hosts [J].

Neely, AN ;

Holder, IA .

JOURNAL OF ENDOTOXIN RESEARCH, 1996, 3 (03) :229-235

[9] PASSIVE PROTECTION BY ANTITOXIN IN EXPERIMENTAL PSEUDOMONAS-AERUGINOSA BURN INFECTIONS [J].

PAVLOVSKIS, OR ;

POLLACK, M ;

CALLAHAN, LT ;

IGLEWSKI, BH .

INFECTION AND IMMUNITY, 1977, 18 (03) :596-602

[10] Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury [J].

Sawa, T ;

Yahr, TL ;

Ohara, M ;

Kurahashi, K ;

Gropper, MA ;

Wiener-Kronish, JP ;

Frank, DW .

NATURE MEDICINE, 1999, 5 (04) :392-398