The magic of the hypoxia-signaling cascade

被引：90

作者：

Benizri, E. ^{[2
]}

Ginouves, A. ^{[2
]}

Berra, E. ^{[1
]}

机构：

[1] CICbioGUNE, Cell Biol & Stem Cells Unit, Derio 48160, Spain

[2] Univ Nice, CNRS, UMR 6543, ISDBC,Ctr Antoine Lacassagne, F-06189 Nice, France

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 7-8期

关键词：

oxygen homeostasis; hypoxia; HIF signaling; physiopathology; therapy;

D O I：

10.1007/s00018-008-7472-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

All organisms respond to changes in their environment by activating complex signaling cascades. The "hypoxia-signaling cascade" is activated in response to low oxygen availability and this activation is central to maintaining oxygen homeostasis and hence to survival. By regulating the transcriptional complex hypoxia-inducible factor, hypoxia is associated with several physiopathological processes. Several strategies, based on the targeting of the hypoxia-signaling cascade, have been developed to treat these pathologies. Our review summarize different aspects of the hypoxic pathway.

引用

页码：1133 / 1149

页数：17

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