Heck reactions in hydrothermal, sub-critical water: water density as an important reaction variable

被引：15

作者：

Gron, LU ^{[1
]}

LaCroix, JE ^{[1
]}

Higgins, CJ ^{[1
]}

Steelman, KL ^{[1
]}

Tinsley, AS ^{[1
]}

机构：

[1] Hendrix Coll, Dept Chem, Conway, AR 72032 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 49期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(01)01860-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Heck coupling reactions of iodobenzene and cyclohexene in sub-critical water illustrate the importance of water density as a reaction variable. Altering the water density from 0.03 to 0.84 g/mL and the reaction pressure from 30 to greater than 213 bar at 225 degreesC changed both product and isomer yields. The multiple physical effects of water density were also explored by the addition of ionic salts. Changing the isothermal state of the liquid water, measurably altered coupling reaction pathways suggesting that chang es in solvent-solute interactions can influence transition states favoring some configurations and disfavoring others. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：8555 / 8557

页数：3

共 16 条

[1] Kinetics and mechanism of cyclohexanol dehydration in high-temperature water [J].