What is a pericyte?

被引：468

作者：

Attwell, David ^{[1
]}

Mishra, Anusha ^{[1
]}

Hall, Catherine N. ^{[2
]}

O'Farrell, Fergus M. ^{[1
]}

Dalkara, Turgay ^{[3
,4
]}

机构：

[1] UCL, Dept Neurosci Physiol & Pharmacol, Gower St, London WC1E 6BT, England

[2] Univ Sussex, Sch Psychol, Brighton, E Sussex, England

[3] Hacettepe Univ, Inst Neurol Sci & Psychiat, TR-06100 Ankara, Turkey

[4] Hacettepe Univ, Dept Neurol, Fac Med, TR-06100 Ankara, Turkey

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2016年 / 36卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

Pericyte; capillary; cerebral blood flow; blood-brain barrier; stroke; BLOOD-BRAIN-BARRIER; MICROVASCULAR PERICYTES; CAPILLARY PERICYTES; IN-VIVO; FLOW; HETEROGENEITY; ISCHEMIA; DIAMETER; DISEASE; STROKE;

D O I：

10.1177/0271678X15610340

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pericytes, spatially isolated contractile cells on capillaries, have been reported to control cerebral blood flow physiologically, and to limit blood flow after ischaemia by constricting capillaries and then dying. Paradoxically, a recent paper dismisses the idea of pericytes controlling cerebral blood flow, despite confirming earlier data showing a role for pericytes. We show that these discrepancies are apparent rather than real, and depend on the new paper defining pericytes differently from previous reports. An objective definition of different sub-classes of pericyte along the capillary bed is needed to develop novel therapeutic approaches for stroke and disorders caused by pericyte malfunction.

引用

页码：451 / 455

页数：5

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