Host-associated genetic import in Campylobacter jejuni

被引:107
作者
McCarthy, Noel D.
Colles, Frances M.
Dingle, Kate E.
Bagnall, Mary C.
Manning, Georgina
Maiden, Martin C. J.
Falush, Daniel
机构
[1] Univ Oxford, Dept Zool, Oxford OX1 3SY, England
[2] Vet Labs Agcy, Weybridge, Surrey, England
基金
英国惠康基金;
关键词
D O I
10.3201/eid1302.060620
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Host association of Campylobacter jejuni was analyzed by using multilocus sequence typing data for 713 isolates from chickens and bovids (cattle and sheep). Commonly used summary measures of genotypes (sequence type and clonal complex) showed poor accuracy, but a method using the full allelic profile showed 80% accuracy in distinguishing isolates from these 2 host groups. We explored the biologic basis of more accurate results with allelic profiles. Strains isolated from specific hosts have imported a substantial number of alleles while circulating in those host species. These results imply that 1) although Campylobacter moves frequently between hosts, most transmission is within species, and 2) lineages can acquire a host signature and potentially adapt to the host through recombination. Assignment using this signature enables improved prediction of source for pathogens that undergo frequent genetic recombination.
引用
收藏
页码:267 / 272
页数:6
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