Oxidative stress, DNA methylation and carcinogenesis

被引:446
作者
Franco, Rodrigo [2 ]
Schoneveld, Onard [2 ]
Georgakilas, Alexandros G. [3 ]
Panayiotidis, Mihalis I. [1 ]
机构
[1] Univ Nevada, Sch Publ Hlth, Reno, NV 89557 USA
[2] NIEHS, Lab Signal Transduct, NIH, Res Triangle Pk, NC 27709 USA
[3] E Carolina Univ, Dept Biol, Thomas Harriot Coll Arts & Sci, Greenville, NC 27858 USA
关键词
oxidative stress; free radicals; reactive oxygen species; oxidative DNA damage; DNA methylation; epigenetics; gene expression; cancer;
D O I
10.1016/j.canlet.2008.02.026
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Transformation of a normal cell to a malignant one requires phenotypic changes often associated with each of the initiation, promotion and progression phases of the carcinogenic process. Genes in each of these phases acquire alterations in their transcriptional activity that are associated either with hypermethylation-induced transcriptional repression (in the case of tumor suppressor genes) or hypomethylation-induced activation (in the case of oncogenes). Growing evidence supports a role of ROS-induced generation of oxidative stress in these epigenetic processes and as such we can hypothesize of potential mode(s) of action by which oxidative stress modulates epigenetic regulation of gene expression. This is of outmost importance given that various components of the epigenetic pathway and primarily aberrant DNA methylation patterns are used as potential biomarkers for cancer diagnosis and prognosis. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:6 / 11
页数:6
相关论文
共 55 条
[1]   The study using wild-type and Ogg1 knockout mice exposed to potassium bromate shows no tumor induction despite an extensive accumulation of 8-hydroxyguanine in kidney DNA [J].
Arai, T ;
Kelly, VP ;
Minowa, O ;
Noda, T ;
Nishimura, S .
TOXICOLOGY, 2006, 221 (2-3) :179-186
[2]  
Baylin SB, 1998, ADV CANCER RES, V72, P141
[3]   DNA methylation and gene silencing in cancer [J].
Baylin S.B. .
Nature Clinical Practice Oncology, 2005, 2 (Suppl 1) :S4-S11
[4]   PERTURBATION OF MAINTENANCE AND DENOVO DNA METHYLATION INVITRO BY UVB (280-340 NM)-INDUCED PYRIMIDINE PHOTODIMERS [J].
BECKER, FF ;
HOLTON, P ;
RUCHIRAWAT, M ;
LAPEYRE, JN .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (18) :6055-6059
[5]   Savior and slayer: the two faces of p53 [J].
Bensaad, K ;
Vousden, KH .
NATURE MEDICINE, 2005, 11 (12) :1278-1279
[6]   THE ESSENTIALS OF DNA METHYLATION [J].
BIRD, A .
CELL, 1992, 70 (01) :5-8
[7]  
Board RE, 2007, BIOMARK INSIGHTS, V2, P307
[8]   Effect of toluene and cresols on Na+K+-ATPase, and serotonin in rat brain [J].
Calderón-Guzmán, D ;
Hernández-Islas, JL ;
Vázquez, IRE ;
Barragán-Mejía, G ;
Hernández-García, E ;
del Angel, DS ;
Juárez-Olguín, H .
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2005, 41 (01) :1-5
[9]   Triggering and modulation of apoptosis by oxidative stress [J].
Chandra, J ;
Samali, A ;
Orrenius, S .
FREE RADICAL BIOLOGY AND MEDICINE, 2000, 29 (3-4) :323-333
[10]   5-METHYL-2'-DEOXYCYTIDINE IN SINGLE-STRANDED-DNA CAN ACT IN CIS TO SIGNAL DE-NOVO DNA METHYLATION [J].
CHRISTMAN, JK ;
SHEIKHNEJAD, G ;
MARASCO, CJ ;
SUFRIN, JR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7347-7351