Oxidative stress, DNA methylation and carcinogenesis

被引：453

作者：

Franco, Rodrigo ^{[2
]}

Schoneveld, Onard ^{[2
]}

Georgakilas, Alexandros G. ^{[3
]}

Panayiotidis, Mihalis I. ^{[1
]}

机构：

[1] Univ Nevada, Sch Publ Hlth, Reno, NV 89557 USA

[2] NIEHS, Lab Signal Transduct, NIH, Res Triangle Pk, NC 27709 USA

[3] E Carolina Univ, Dept Biol, Thomas Harriot Coll Arts & Sci, Greenville, NC 27858 USA

来源：

CANCER LETTERS | 2008年 / 266卷 / 01期

关键词：

oxidative stress; free radicals; reactive oxygen species; oxidative DNA damage; DNA methylation; epigenetics; gene expression; cancer;

D O I：

10.1016/j.canlet.2008.02.026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Transformation of a normal cell to a malignant one requires phenotypic changes often associated with each of the initiation, promotion and progression phases of the carcinogenic process. Genes in each of these phases acquire alterations in their transcriptional activity that are associated either with hypermethylation-induced transcriptional repression (in the case of tumor suppressor genes) or hypomethylation-induced activation (in the case of oncogenes). Growing evidence supports a role of ROS-induced generation of oxidative stress in these epigenetic processes and as such we can hypothesize of potential mode(s) of action by which oxidative stress modulates epigenetic regulation of gene expression. This is of outmost importance given that various components of the epigenetic pathway and primarily aberrant DNA methylation patterns are used as potential biomarkers for cancer diagnosis and prognosis. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：6 / 11

页数：6

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