1H-magnetic resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders

被引：44

作者：

Gabis, Lidia ^{[1
,2
]}

Huang, Wei ^{[3
]}

Azizian, Allen ^{[4
]}

DeVincent, Carla ^{[5
]}

Tudorica, Alina ^{[6
]}

Kesner-Baruch, Yael ^{[1
,2
]}

Roche, Patricia ^{[6
]}

Pomeroy, John ^{[5
]}

机构：

[1] Safra Childrens Hosp, Weinberg Child Dev Ctr, IL-52621 Tel Hashomer, Israel

[2] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel

[3] Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY 10021 USA

[4] Univ Calif Los Angeles, Neuropsychiat Inst & Hosp, Los Angeles, CA 90024 USA

[5] SUNY Stony Brook, Dept Pediat, Stony Brook, NY 11794 USA

[6] SUNY Stony Brook, Dept Radiol, Stony Brook, NY 11794 USA

来源：

JOURNAL OF CHILD NEUROLOGY | 2008年 / 23卷 / 07期

关键词：

language; brain imaging; H-1-magnetic resonance spectroscopy; autism spectrum disorders;

D O I：

10.1177/0883073808315423

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study assessed metabolic functioning of regional brain areas to address whether there is a neurometabolic profile reflecting the underlying neuropathology in individuals with autism spectrum disorders, and if varied profiles correlate with the clinical subtypes. Thirteen children (7-16 years) with autism spectrum disorders and 8 typically developing children were compared on H-1-magnetic resonance spectroscopy data collected from hippocampus-amygdala and cerebellar regions. The autism spectrum disorder group had significantly lower N-acetyl-aspartate/creatine ratios bilaterally in the hippocampus-amygdala but not cerebellum, whereas myo-inositol/creatine was significantly increased in all measured regions. Choline/creatine was also significantly elevated in the left hippocampus-amygdala and cerebellar regions of children with autism spectrum disorder. Comparisons within the autism spectrum disorder group when clinically subdivided by history of speech delay revealed significant metabolic ratio differences. Magnetic resonance spectroscopy can provide important information regarding abnormal brain metabolism and clinical classification in autism spectrum disorders.

引用

页码：766 / 774

页数：9

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