Synechocystis strain PCC 6803 cya2, a prokaryotic gene that encodes a guanylyl cyclase

被引：43

作者：

de Alda, JAGO

Ajlani, G

Houmard, J

机构：

[1] Ecole Normale Super, CNRS, UMR8543, F-75230 Paris 05, France

[2] CEA Saclay, CNRS, URA2096, DBCM,SBPM, F-91191 Gif Sur Yvette, France

来源：

JOURNAL OF BACTERIOLOGY | 2000年 / 182卷 / 13期

关键词：

D O I：

10.1128/JB.182.13.3839-3842.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Synechocystis strain PCC 6803 exhibits similar levels of cyclic AMP (cAMP) and cyclic GMP (cGMP). A thorough analysis of its genome showed that Cya2 (S110646) has all the sequence determinants required in terms of activity and purine specificity for being a guanylyl cyclase, Insertional mutagenesis of cya2 caused a marked reduction in cGMP content without altering the cAMP content. Thus, Cya2 represents the first example of a prokaryotic guanylyl cyclase.

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页码：3839 / 3842

页数：4

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