Differential prefrontal-temporal neural correlates of semantic processing in children

被引:48
作者
Blumenfeld, Henrike K. [1 ]
Booth, James R. [1 ]
Burman, Douglas D. [1 ]
机构
[1] Northwestern Univ, Dept Comp Sci & Disorders, Evanston, IL 60208 USA
关键词
semantic; children; fMRI; brain development; auditory; visual; brain-behavior correlation;
D O I
10.1016/j.bandl.2005.07.004
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
This study used functional magnetic resonance imaging (fMRI) to examine brain-behavior correlations in a group of 16 children (9- to 12-year-olds). Activation was measured during a semantic judgment task presented in either the visual or auditory modality that required the individual to determine whether a final word was related in meaning to one of two previous words (e.g., found-tank-lost). The main finding was that higher performers (i.e., accuracy) were associated with more activation in posterior representational systems including the inferior and middle temporal gyri, whereas lower performers were associated with more activation in anterior regions including the inferior and middle frontal gyri. This pattern of results was interpreted as reflecting an elaborated semantic representational system in temporal areas for the high accuracy performers that allowed them to efficiently and accurately make meaning based judgments. The low accuracy performers may have an inaccurate or weakly interconnected semantic system that results in greater use of frontal areas in a feature selection process. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:226 / 235
页数:10
相关论文
共 64 条
[51]   Functional neuroanatomical differences between adults and school-age children in the processing of single words [J].
Schlaggar, BL ;
Brown, TT ;
Lugar, HM ;
Visscher, KM ;
Miezin, FM ;
Petersen, SE .
SCIENCE, 2002, 296 (5572) :1476-1479
[52]   Functional magnetic resonance imaging evidence for right-hemisphere involvement in processing unusual semantic relationships [J].
Seger, CA ;
Desmond, JE ;
Glover, GH ;
Gabrieli, JDE .
NEUROPSYCHOLOGY, 2000, 14 (03) :361-369
[53]   BRAIN-REGIONS ASSOCIATED WITH ACQUISITION AND RETRIEVAL OF VERBAL EPISODIC MEMORY [J].
SHALLICE, T ;
FLETCHER, P ;
FRITH, CD ;
GRASBY, P ;
FRACKOWIAK, RSJ ;
DOLAN, RJ .
NATURE, 1994, 368 (6472) :633-635
[54]   Disruption of posterior brain systems for reading in children with developmental dyslexia [J].
Shaywitz, BA ;
Shaywitz, SE ;
Pugh, KR ;
Mencl, WE ;
Fulbright, RK ;
Skudlarski, P ;
Constable, RT ;
Marchione, KE ;
Fletcher, JM ;
Lyon, GR ;
Gore, JC .
BIOLOGICAL PSYCHIATRY, 2002, 52 (02) :101-110
[55]  
Talairach G., 1988, Planar Stereotaxic Atlas of the Human Brain
[56]   Effects of repetition and competition on activity in left prefrontal cortex during word generation [J].
Thompson-Schill, SL ;
D'Esposito, M ;
Kan, IP .
NEURON, 1999, 23 (03) :513-522
[57]   Role of left inferior prefrontal cortex in retrieval of semantic knowledge: A reevaluation [J].
Thompson-Schill, SL ;
D'Esposito, M ;
Aguirre, GK ;
Farah, MJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (26) :14792-14797
[58]   Functional anatomy of a common semantic system for words and pictures [J].
Vandenberghe, R ;
Price, C ;
Wise, R ;
Josephs, O ;
Frackowiak, RSJ .
NATURE, 1996, 383 (6597) :254-256
[59]   Recovering meaning:: Left prefrontal cortex guides controlled semantic retrieval [J].
Wagner, AD ;
Paré-Blagoev, EJ ;
Clark, J ;
Poldrack, RA .
NEURON, 2001, 31 (02) :329-338
[60]   Semantic repetition priming for verbal and pictorial knowledge: A functional MRI study of left inferior prefrontal cortex [J].
Wagner, AD ;
Desmond, JE ;
Demb, JB ;
Glover, GH ;
Gabrieli, JDE .
JOURNAL OF COGNITIVE NEUROSCIENCE, 1997, 9 (06) :714-726