Exploratory studies toward a total synthesis of the marine ascidian metabolite perophoramidine

被引：25

作者：

Evans, Michael A. ^{[1
]}

Sacher, Joshua R. ^{[1
]}

Weinreb, Steven M. ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

TETRAHEDRON | 2009年 / 65卷 / 33期

基金：

美国国家卫生研究院;

关键词：

Natural product; Alkaloid; Heck reaction; Carbonylation; Amidines; CATALYZED QUEUING-PROCESSES; EMPLOYING CARBON-MONOXIDE; BIOMIMETIC APPROACH; RELAY SWITCH; PALLADIUM; COMMUNESIN; CYCLIZATION; ALKALOIDS; BIOSYNTHESIS; CONSTRUCTION;

D O I：

10.1016/j.tet.2008.10.060

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A strategy for a total synthesis of the marine alkaloid perophoramidine has been investigated. Key steps which have been tested include a tandem intramolecular Heck/carbonylation reaction and a stereoselective allylation of a pentacyclic delta-lactam to produce the C-4/20 vicinal quaternary centers having the requisite relative configuration of the metabolite. (C) 2008 Published by Elsevier Ltd.

引用

页码：6712 / 6719

页数：8

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