Association studies on the porcine RETN, UCP1, UCP3 and ADRB3 genes polymorphism with fatness traits

被引：25

作者：

Cieslak, Jakub ^{[1
]}

Nowacka-Woszuk, Joanna ^{[1
]}

Bartz, Magdalena ^{[1
]}

Fijak-Nowak, Honorata ^{[1
]}

Grzes, Maria ^{[1
]}

Szydiowski, Maciej ^{[1
]}

Switonski, Marek ^{[1
]}

机构：

[1] Poznan Univ Life Sci, Dept Anim Breeding & Genet, PL-60637 Poznan, Poland

来源：

MEAT SCIENCE | 2009年 / 83卷 / 03期

关键词：

Pig; Fatness; Polymorphism; RETN; UCP1; UCP3; ADRB3; GROWTH-RATE; BIRTH-WEIGHT; OBESITY; RECEPTOR; CARCASS; PIGS;

D O I：

10.1016/j.meatsci.2009.07.001

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Searching for effects of candidate gene polymorphisms on fatness traits is an important goal for pig industry. In this study we evaluated polymorphism of four porcine genes involved in energy metabolism (RETN, UCP1, UCP3 and ADRB3). Moreover, their association with fat deposition traits was analyzed in two breeds (Polish Landrace, Polish Large White) and a Polish synthetic line (L990). Altogether, five SNPs were identified, including two novel ones in the 5'-flanking region of the RETN gene and a novel missense substitution in the UCP3. Distribution of these polymorphisms in the studied five breeds and the synthetic line was not uniform, Two of the analyzed SNPs: g.-178G > A in the RETN and g.946C > T in the UCP3 gene revealed a significant association with abdominal fat weight or backfat thickness. Such associations were not observed for the UCP1 or ADRB3 gene polymorphisms. Our study showed that polymorphisms of the UCP3 and RETN genes are potentially associated with porcine fatness traits. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：551 / 554

页数：4

共 24 条

[1] The adipocyte as an active participant in energy balance and metabolism [J].

Badman, Michael K. ;

Flier, Jeffrey S. .

GASTROENTEROLOGY, 2007, 132 (06) :2103-2115

[2] The uncoupling proteins, a review [J].

Boss, O ;

Muzzin, P ;

Giacobino, JP .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1998, 139 (01) :1-9

[3] Partial cloning, cytogenetic and linkage mapping of the porcine resistin (RSTN) gene [J].

Cepica, S ;

Rohrer, GA ;

Masopust, M ;

Kubickova, S ;

Musilova, P ;

Rubes, J .

ANIMAL GENETICS, 2002, 33 (05) :381-383

[4] Identification of target sequences for association studies -: analysis of the pig FABP3 and FABP4 loci using comparative genomics methods [J].

Chmurzynska, A. ;

Cieslak, J. ;

Jankowski, T. ;

Szydlowski, M. ;

Switonski, M. .

JOURNAL OF ANIMAL AND FEED SCIENCES, 2008, 17 (02) :191-201

[5] Structural analysis and haplotype diversity in swine LEP and MC4R genes [J].

D'Andrea, M. ;

Pilla, F. ;

Giuffra, E. ;

Waddington, D. ;

Archibald, A. L. .

JOURNAL OF ANIMAL BREEDING AND GENETICS, 2008, 125 (02) :130-136

[6]

FAN B, ANIMAL GENETICS, DOI DOI 10.1111/J.1365-2009.01853.X

[7] The Fat Mass and Obesity-Associated (FTO) Gene is Associated with Intramuscular Fat Content and Growth Rate in the Pig [J].

Fan, Bin ;

Du, Zhi-Qiang ;

Rothschild, Max F. .

ANIMAL BIOTECHNOLOGY, 2009, 20 (02) :58-70

[8] Polymorphism at the ovine β3-adrenergic receptor locus:: associations with birth weight, growth rate, carcass composition and cold survival [J].

Forrest, RH ;

Hickford, JGH ;

Hogan, A ;

Frampton, C .

ANIMAL GENETICS, 2003, 34 (01) :19-25

[9] Association of the ADRB3 gene with birth weight and growth rate to weaning in New Zealand Romney sheep [J].

Horrell, A. ;

Forrest, R. H. J. ;

Zhou, H. ;

Fang, Q. ;

Hickford, J. G. H. .

ANIMAL GENETICS, 2009, 40 (02) :251-251

[10] Mammalian mitochondrial uncoupling proteins [J].

Jezek, P ;

Garlid, KD .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1998, 30 (11) :1163-1168

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