Genetic basis of rheumatoid arthritis

被引：72

作者：

Orozco, G. ^{[1
]}

Rueda, B. ^{[1
]}

Martin, J. ^{[1
]}

机构：

[1] CSIC, Inst Parasitol & Biomed Lopez Neyra, Granada 18100, Spain

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2006年 / 60卷 / 10期

关键词：

rheumatoid arthritis; genetic factors;

D O I：

10.1016/j.biopha.2006.09.003

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Rheumatoid arthritis (RA) is a clinically heterogeneous condition with a complex aetiology in which environmental and genetic factors are implicated, The contribution of human leukocyte antigen (HLA) genes, particularly the HLA-DRB1 gene, to RA genetic predisposition was the first described, and remains as the best characterised single genetic risk factor contributing to RA. However, it has been estimated that only 30% of the genetic contribution to RA can be attributed to HLA genes and it is suggested that other non-HLA genes may play a relevant role in RA susceptibility. Linkage studies and association studies are the two main strategies used in the investigation of genetic factors contributing to complex genetic traits. In this work we review the progress made in the field of RA genetics, focusing mainly on the contribution of candidate gene association studies to the dissection of RA genetic risk factors. (c) 2006 Elsevier Masson SAS. All rights reserved.

引用

页码：656 / 662

页数：7

共 114 条

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