Improvement of the chemoenzymatic synthesis of both enantiomers of keto-protected 4-amino-2-pentanone

被引：7

作者：

Besse, P ^{[1
]}

Ciblat, S

Canet, JL

Troin, Y

Veschambre, H

机构：

[1] Univ Clermont Ferrand 2, CNRS, UMR 6504, Lab Synthese Electrosynthese & Etud Syst Interet, F-63177 Clermont Ferrand, France

[2] Ecole Natl Super Chim Clermont Ferrand, Lab Chim Heterocycles & Glucides, EA 987, F-63174 Aubiere, France

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(00)00167-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An improved enantioselective synthesis (five steps, 37-44% yield versus seven to 10 steps, 13.5 and 12% yield, respectively) of both enantiomers of keto-protected 4-amino-2-pentanone has been realized, the key step being the microbiological reduction of 2,4-pentanedione. This study shows that microbiological reductions of the mono acetal-protected 2,4-pentanedione afforded in most cases the corresponding ketol with moderate to excellent enantiomeric excesses, depending on the microorganism used. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2211 / 2219

页数：9

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