Naturally occurring primary deficiencies of the immune system

被引：120

作者：

Fischer, A

CavazzanaCalvo, M

DesaintBasile, G

DeVillartay, JP

DiSanto, JP

Hivroz, C

RieuxLaucat, F

LeDeist, F

机构：

[1] Unité INSERM U 429, Hop. Necker-Enfants Malades, 75 743 Paris cedex 15, 149, Rue de Sèvres

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 1997年 / 15卷

关键词：

primary immunodeficiencies; severe combined immunodeficiencies; T lymphocytes; regulation; apoptosis;

D O I：

10.1146/annurev.immunol.15.1.93

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Naturally occurring genetic disorders of the immune system provide many models for the study of its development and function. In a way, their analysis complements the information provided by the generation of genetic defects in mice created using homologous recombination techniques. In this review, the recent findings made in three areas are focused upon deficiencies in T cell differentiation and in T lymphocyte activation, and on the control process of peripheral immune response.

引用

页码：93 / 124

页数：32

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