Adipose tissue cells, lipotransfer and cancer: A challenge for scientists, oncologists and surgeons

被引：75

作者：

Bertolini, Francesco ^{[1
]}

Lohsiriwat, Visnu ^{[2
,3
]}

Petit, Jean-Yves ^{[2
]}

Kolonin, Mikhail G. ^{[4
]}

机构：

[1] European Inst Oncol, Lab Hematol Oncol, I-20141 Milan, Italy

[2] European Inst Oncol, Div Plast Surg, I-20141 Milan, Italy

[3] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Surg, Bangkok 10700, Thailand

[4] Univ Texas Hlth Sci Ctr Houston, Brown Fdn, Inst Mol Med Prevent Human Dis, Ctr Stem Cell & Regenerat Med, Houston, TX USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2012年 / 1826卷 / 01期

关键词：

Cancer; adipose tissue; adipose progenitors; obesity; angiogenesis; MESENCHYMAL STEM-CELLS; AUTOLOGOUS FAT TRANSPLANTATION; BREAST-CANCER; PROGENITOR-CELLS; STROMAL CELLS; OBESITY; ADIPOCYTES; GROWTH; AUGMENTATION; MECHANISMS;

D O I：

10.1016/j.bbcan.2012.04.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Despite recent evidence of the cancer-promoting role of adipose tissue-derived progenitor and differentiated cells, the use of lipotransfer for tissue/organ reconstruction after surgical removal of cancer is increasing worldwide. Here we discuss in a multidisciplinary fashion the preclinical data connecting obesity, adipose cells and cancer progression, as well as the clinical data concerning safety of lipotransfer procedures in cancer patients. A roadmap towards a more rationale use of lipotransfer in oncology is urgently needed and should include preclinical studies to dissect the roles of different adipose tissue-derived cells, the evaluation of drugs currently candidate to inhibit the interaction between adipose and tumor cells, and carefully designed clinical trials to investigate the safety of lipotransfer procedures in cancer patients. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：209 / 214

页数：6

共 82 条

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Cell-assisted lipotransfer for cosmetic breast augmentation: Supportive use of adipose-derived stem/stromal cells [J].