Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases

被引：321

作者：

Cao, Yihai ^{[1
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumour & Cell Biol, S-17177 Stockholm, Sweden

来源：

NATURE REVIEWS DRUG DISCOVERY | 2010年 / 9卷 / 02期

基金：

瑞典研究理事会; 欧洲研究理事会;

关键词：

ENDOTHELIAL GROWTH-FACTOR; MESENCHYMAL STEM-CELLS; MATRIX-METALLOPROTEINASE INHIBITION; BONE-MARROW; PROGENITOR CELLS; STROMAL CELLS; FAT TISSUE; STIMULATES ANGIOGENESIS; LEPTIN LEVELS; ADIPONECTIN;

D O I：

10.1038/nrd3055

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Current pharmacotherapeutic options for treating obesity and related metabolic disorders remain limited and ineffective. Emerging evidence shows that modulators of angiogenesis affect the expansion and metabolism of fat mass by regulating the growth and remodelling of the adipose tissue vasculature. Pharmacological manipulation of adipose tissue neovascularization by angiogenic stimulators and inhibitors might therefore offer a novel therapeutic option for the treatment of obesity and related metabolic disorders. This Perspective discusses recent progress in understanding the molecular mechanisms that control adipose tissue angiogenesis and in defining potential new vascular targets and approaches for the treatment of this group of diseases.

引用

页码：107 / 115

页数：9

共 135 条

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