Use of an acetylenic sulfone as an alkene dipole equivalent in the synthesis of (+/-)-pumiliotoxin C

被引：18

作者：

Back, TG

Nakajima, K

机构：

[1] Department of Chemistry, University of Calgary, Calgary

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0040-4039(96)02506-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cycloaddition of methyl cis-2-amino-trans-6-methylcyclohexanecarboxylate (3) with 1-p-(toluenesulfonyl)-1-pentyne (4) afforded the corresponding enaminone 2, that was in turn reduced to (+/-)-pumiliotoxin C (1). The acetylenic sulfone 4 thus functions as the synthetic equivalent of the alkene dipole 5 in this process. (C) 1997, Elsevier Science Ltd.

引用

页码：989 / 992

页数：4

共 40 条

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