Effect of pesticides on cell survival in liver and brain rat tissues

被引：87

作者：

Astiz, Mariana ^{[1
]}

de Alaniz, Maria J. T. ^{[1
]}

Marra, Carlos Alberto ^{[1
]}

机构：

[1] Natl Univ La Plata, Fac Ciencias Med, Catedra Bioquim & Biol Mol,CONICET, INIBIOLP Inst Invest Bioquim La Plata,CCT La Plat, RA-1900 La Plata, Argentina

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2009年 / 72卷 / 07期

关键词：

Pesticides; Brain; Liver; Dimethoate; Glyphosate; Zineb; Oxidative stress; Cell death; Mitochondria; Cardiolipin; ELECTRON-TRANSPORT CHAIN; PARKINSONS-DISEASE; REACTIVE OXYGEN; OXIDATIVE STRESS; CYTOCHROME-C; LIPID-PEROXIDATION; IN-VIVO; ANTIOXIDANT STATUS; MITOCHONDRIAL DYSFUNCTION; CARDIOLIPIN PEROXIDATION;

D O I：

10.1016/j.ecoenv.2009.05.001

中图分类号：

X [环境科学、安全科学];

学科分类号：

083001 [环境科学];

摘要：

Pesticides are the main environmental factor associated with the etiology of human neurodegenerative disorders such as Parkinson's disease. Our laboratory has previously demonstrated that the treatment of rats with low doses of dimethoate, zineb or glyphosate alone or in combination induces oxidative stress (OS) in liver and brain. The aim of the present work was to investigate if the pesticide-induced OS was able to affect brain and liver cell survival. The treatment of Wistar rats with the pesticides (i.p. 1/250 LD50, three times a week for 5 weeks) caused loss of mitochondrial transmembrane potential and cardiolipin content, especially in substantia nigra (SN), with a concomitant increase of fatty acid peroxidation. The activation of calpain apoptotic cascade (instead of the caspase-dependent pathway) would be responsible for the DNA fragmentation pattern observed. Thus, these results may contribute to understand the effect(s) of chronic and simultaneous exposure to pesticides on cell survival. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：2025 / 2032

页数：8

共 84 条

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