Cytokines and T cells in host defense

被引:61
作者
Hunter, CA
Reiner, SL
机构
[1] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Med, Philadelphia, PA 19104 USA
[3] Univ Penn, Leonard & Madlyn Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0952-7915(00)00110-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Soluble and cell-bound ligands profoundly influence the differentiative fate of lymphocytes during an immune response, Recent advances have been made in understanding the role of cytokine signals and costimulatory signals in the regulation of T cell responses associated with resistance or susceptibility to infection. There has also been recent progress in defining the requirements for the generation and maintenance of immunologic memory, a critical component of adaptive immunity.
引用
收藏
页码:413 / 418
页数:6
相关论文
共 74 条
[1]   Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis [J].
Akiba, H ;
Miyahira, Y ;
Atsuta, M ;
Takeda, K ;
Nohara, C ;
Futagawa, T ;
Matsuda, H ;
Aoki, T ;
Yagita, H ;
Okumura, K .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (02) :375-380
[2]   Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection [J].
Altare, F ;
Lammas, D ;
Revy, P ;
Jouanguy, E ;
Döffinger, R ;
Lamhamedi, S ;
Drysdale, P ;
Scheel-Toellner, D ;
Girdlestone, J ;
Darbyshire, P ;
Wadhwa, M ;
Dockrell, H ;
Salmon, M ;
Fischer, A ;
Durandy, A ;
Casanova, JL ;
Kumararatne, DS .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (12) :2035-2040
[3]   Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency [J].
Altare, F ;
Durandy, A ;
Lammas, D ;
Emile, JF ;
Lamhamedi, S ;
Le Deist, F ;
Drysdale, P ;
Jouanguy, E ;
Döffinger, R ;
Bernaudin, F ;
Jeppsson, O ;
Gollob, JA ;
Meinl, E ;
Segal, AW ;
Fischer, A ;
Kumararatne, D ;
Casanova, JL .
SCIENCE, 1998, 280 (5368) :1432-1435
[4]   TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation [J].
Bachmann, MF ;
Wong, BR ;
Josien, R ;
Steinman, RM ;
Oxenius, A ;
Choi, Y .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (07) :1025-1031
[5]   Help for cytotoxic-T-cell responses is mediated by CD40 signalling [J].
Bennett, SRM ;
Carbone, FR ;
Karamalis, F ;
Flavell, RA ;
Miller, JFAP ;
Heath, WR .
NATURE, 1998, 393 (6684) :478-480
[6]  
Bohn E, 1998, J IMMUNOL, V160, P299
[7]   T cell affinity maturation by selective expansion during infection [J].
Busch, DH ;
Pamer, EG .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (04) :701-709
[8]   Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon γ production from CD4+ versus CD8+ T cells [J].
Carter, LL ;
Murphy, KM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (08) :1355-1360
[9]   Two roads diverged:: Interferon α/β- and interleukin 12-mediated pathways in promoting T cell interferon γ responses during viral infection [J].
Cousens, LP ;
Peterson, R ;
Hsu, S ;
Dorner, A ;
Altman, JD ;
Ahmed, R ;
Biron, CA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (08) :1315-1327
[10]  
de Jong R, 1998, SCIENCE, V280, P1435