Full-Thickness Heart Repair with an Engineered Multilayered Myocardial Patch in Rat Model

被引：32

作者：

Pok, Seokwon ^{[1
,2
]}

Stupin, Igor V. ^{[3
]}

Tsao, Christopher ^{[1
]}

Pautler, Robia G. ^{[4
]}

Gao, Yang ^{[1
]}

Nieto, Raymond M. ^{[2
]}

Tao, Ze-Wei ^{[5
]}

Fraser, Charles D., Jr. ^{[2
]}

Annapragada, Ananth V. ^{[3
]}

Jacot, Jeffrey G. ^{[1
,2
,5
]}

机构：

[1] Rice Univ, Dept Bioengn, Houston, TX 77005 USA

[2] Texas Childrens Hosp, Div Congenital Heart Surg, Houston, TX 77030 USA

[3] Texas Childrens Hosp, Dept Basic Radiol Res, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Mol Physiol, Houston, TX 77030 USA

[5] Univ Colorado Denver, Dept Bioengn, Anschutz Med Campus, Aurora, CO 80045 USA

来源：

ADVANCED HEALTHCARE MATERIALS | 2017年 / 6卷 / 05期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

IN-VIVO DEGRADATION; MATRIX; VITRO; EXPERIENCE; CHITOSAN;

D O I：

10.1002/adhm.201600549

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

In a rat model of right free wall replacement, the transplantation of an engineered multilayered myocardial patch fabricated from a polycaprolactone membrane supporting a chitosan/heart matrix hydrogel induces significant muscular and vascular remodeling and results in a significantly higher right ventricular ejection fraction compared to use of a commercially available pericardium patch. [GRAPHICS] .

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