Attenuation of spontaneous opiate withdrawal in mice by the anandamide transport inhibitor AM404

被引：39

作者：

Del Arco, I

Navarro, M

Bilbao, A

Ferrer, B

Piomelli, D

De Fonseca, FR

机构：

[1] Fdn Hosp Carlos Haya, Malaga 29010, Spain

[2] Univ Complutense, Dept Psicobiol, Madrid 28224, Spain

[3] Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2002年 / 454卷 / 01期

关键词：

AM404; anandamide; morphine withdrawal;

D O I：

10.1016/S0014-2999(02)02483-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The endogenous cannabinoid, anandamide, has been shown to attenuate naloxone-precipitated opiate withdrawal in rodents. Here we show that the spontaneous, but not the naloxone-precipitated withdrawal syndrome in morphine-dependent mice is attenuated by the inhibitor of carrier-mediated anandamide transport N-(4-hydroxyphenyl) arachidonylethanolamide (AM404) (2 and 10 mg/kg, i.p.). These results suggest that spontaneous but not opioid antagonist-precipitated withdrawal is associated with dynamic changes in endogenous cannabinoid signaling. (C) 2002 Elsevier Science B.V All rights reserved.

引用

收藏

页码：103 / 104

页数：2

相关论文

共 8 条

[1] Reversal of dopamine D2 receptor responses by an anandamide transport inhibitor [J].

Beltramo, M ;

de Fonseca, FR ;

Navarro, M ;

Calignano, A ;

Gorriti, MA ;

Grammatikopoulos, G ;

Sadile, AG ;

Giuffrida, A ;

Piomelli, D .

JOURNAL OF NEUROSCIENCE, 2000, 20 (09) :3401-3407

[2] Dopamine activation of endogenous cannabinoid signaling in dorsal striatum [J].

Giuffrida, A ;

Parsons, LH ;

Kerr, TM ;

de Fonseca, FR ;

Navarro, M ;

Piomelli, D .

NATURE NEUROSCIENCE, 1999, 2 (04) :358-363

[3] Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice [J].

Ledent, C ;

Valverde, O ;

Cossu, C ;

Petitet, F ;

Aubert, LF ;

Beslot, F ;

Böhme, GA ;

Imperato, A ;

Pedrazzini, T ;

Roques, BP ;

Vassart, G ;

Fratta, W ;

Parmentier, M .

SCIENCE, 1999, 283 (5400) :401-404

[4] Pharmacological and biochemical interactions between opioids and cannabinoids [J].

Manzanares, J ;

Corchero, J ;

Romero, J ;

Fernández-Ruiz, JJ ;

Ramos, JA ;

Fuentes, JA .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1999, 20 (07) :287-294

[5] CB1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats [J].

Navarro, M ;

Chowen, J ;

Carrera, MRA ;

del Arco, I ;

Villanúa, MA ;

Martin, Y ;

Roberts, AJ ;

Koob, GF ;

de Fonseca, FR .

NEUROREPORT, 1998, 9 (15) :3397-3402

[6] Functional interaction between opioid and cannabinoid receptors in drug self-administration [J].

Navarro, M ;

Carrera, MRA ;

Fratta, W ;

Valverde, O ;

Cossu, G ;

Fattore, L ;

Chowen, JA ;

Gómez, R ;

del Arco, I ;

Villanúa, MA ;

Maldonado, R ;

Koob, GF ;

de Fonseca, FR .

JOURNAL OF NEUROSCIENCE, 2001, 21 (14) :5344-5350

[7] Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu 1 opioid receptor mechanism [J].

Tanda, G ;

Pontieri, FE ;

DiChiara, G .

SCIENCE, 1997, 276 (5321) :2048-2050

[8] ANANDAMIDE DECREASES NALOXONE-PRECIPITATED WITHDRAWAL SIGNS IN MICE CHRONICALLY TREATED WITH MORPHINE [J].

VELA, G ;

RUIZGAYO, M ;

FUENTES, JA .

NEUROPHARMACOLOGY, 1995, 34 (06) :665-668