No evidence for an mtDNA role in sperm motility:: Data from complete sequencing of asthenozoospermic males

被引：53

作者：

Pereira, Luisa ^{[1
]}

Goncalves, Joao

Franco-Duarte, Ricardo

Silva, Julia

Rocha, Tiago

Arnold, Christiane

Richards, Martin

Macaulay, Vincent

机构：

[1] Univ Porto, Inst Patol & Imunol Mol, Oporto, Portugal

[2] Univ Porto, Fac Med, Oporto, Portugal

[3] Ctr Genet Humana, Inst Nacl Saude Dr Ricardo Jorge, Lisbon, Portugal

[4] Maternidade Dr Alfredo Da Costa, Lisbon, Portugal

[5] Univ Leeds, Inst Integrat & Comparat Biol, Fac Biol Sci, Leeds, W Yorkshire, England

[6] Univ Glasgow, Dept Stat, Glasgow, Lanark, Scotland

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 2007年 / 24卷 / 03期

关键词：

mtDNA; complete sequences; asthenozoospermia; association;

D O I：

10.1093/molbev/msm004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The first complete mitochondrial DNA (mtDNA) sequences (similar to 16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played by mtDNA in male fertility, once supported by haplogroup association studies based on the screening of hypervariable region I. The hypothesis of maternally driven selection acting in male reproductive success must thus be treated with caution.

引用

页码：868 / 874

页数：7

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