Formal total synthesis of (+)-trehazolin. Application of an asymmetric aldol-olefin metathesis approach to the synthesis of functionalized cyclopentenes

被引：61

作者：

Crimmins, MT ^{[1
]}

Tabet, EA ^{[1
]}

机构：

[1] Univ N Carolina, Venable & Kenan Labs Chem, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 66卷 / 11期

关键词：

D O I：

10.1021/jo015568k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric synthesis of the aminocyclopentitol pseudosugar of trehazolin has been completed. The synthesis hinges on an asymmetric aldol-ring closing metathesis strategy to construct the five-membered ring with control of both the relative and absolute stereochemistry.

引用

页码：4012 / 4018

页数：7

共 31 条

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