On the feasibility to detect and to quantify prepulse-elicited reaction in prepulse inhibition of the acoustic startle reflex in humans

被引:24
作者
Csomor, PA
Vollenweider, FX
Feldon, J
Yee, BK
机构
[1] Swiss Fed Inst Technol, Lab Behav Neurobiol, CH-8603 Schwerzenbach, Switzerland
[2] Univ Zurich, Psychiat Hosp, CH-8029 Zurich, Switzerland
关键词
attention; prepulse inhibition; schizophrenia; sensorimotor gating; prepulse detection; startle; human;
D O I
10.1016/j.bbr.2005.03.020
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 [法学]; 0303 [社会学]; 030303 [人类学]; 04 [教育学]; 0402 [心理学];
摘要
The possibility that the prepulse stimulus typically employed in the studies of prepulse inhibition (PPI) can produce observable response has been questioned recently. Conflicting reports range from observations of prepulse-elicited startle reaction to a complete lack of detectable prepulse-elicited reactions in healthy volunteers. This controversy is subjected to critical examination in the present study. The ability of prepulse stimuli to induce PPI and to elicit measurable responses was examined in two separate experiments using prepulses ranging from 6 to 18 dB above background (experiment 1), or I to 5 dB above background (experiment 2). Three levels of pulse stimulus were employed: 95, 105 and 115 dB(A). Clear PPI and prepulse-elicited reaction were obtained in experiment 1, while neither effect was evident in experiment 2. Non-startle-eliciting prepulses that are of sufficient intensities to induce reliable PPI are associated with detectable and quantifiable response, confirming that direct evaluation of prepulse-processing is feasible and practical. This provides an additional measure of theoretical and potentially clinical relevance to PPI, and it ought to be included in future studies in patients as well as healthy subjects. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:256 / 263
页数:8
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