Injectable gels for tissue engineering

被引:341
作者
Gutowska, A
Jeong, B
Jasionowski, M
机构
[1] Pacific NW Natl Lab, Mat & Chem Res Sect, Richland, WA 99352 USA
[2] Univ Gdansk, PL-80952 Gdansk, Poland
来源
ANATOMICAL RECORD | 2001年 / 263卷 / 04期
关键词
tissue engineering; injectable gels;
D O I
10.1002/ar.1115
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Recently, tissue engineering approaches using injectable, in situ gel forming systems have been reported. In this review, the gelation processes and several injectable systems that exhibit in situ gel formation at physiological conditions are discussed. Applications of selected injectable systems (alginate, chitosan, hyaluronan, polyethylene oxide/polypropylene oxide) in tissue engineering are also described. Injectable polymer formulation can gel in vivo in response to temperature change (thermal gelation), pH change, ionic cross-linking, or solvent exchange. Kinetics of gelation is directly affected by its mechanism. Injectable formulations offer specific advantages over preformed scaffolds such as: possibility of a minimally invasive implantation, an ability to fill a desired shape, and easy incorporation of various therapeutic agents. Several factors need to be considered before an injectable gel can be selected as a candidate for tissue engineering applications. Apart from tissue-specific cell-matrix interactions, the following gel properties need to be considered: gelation kinetics, matrix resorption rate, possible toxicity of degradation products and their elimination routes, and finally possible interference of the gel matrix with histogenesis. Anat Rec 263:342-349, 2001. (C) 2001 Wiley-Liss, Inc.
引用
收藏
页码:342 / 349
页数:8
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