Constituents of Trigonostemon heterophyllus

被引：35

作者：

Dong, Shi-Hui ^{[1
]}

Liu, Hong-Bing ^{[1
]}

Xu, Cheng-Hui ^{[1
]}

Ding, Jian ^{[1
]}

Yue, Jian-Min ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 12期

关键词：

DAPHNANE-TYPE DITERPENOIDS; APOPTOSIS; ASSAY;

D O I：

10.1021/np200772n

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six new diterpenoids, 1-6, a new prenylated sesquiterpenoid, 7, and six known compounds were isolated from Trigonostemon heterophyllus. The structures of 1-7 were elucidated on the basis of NMR and MS analysis. The daphnane diterpenoids trigoheterins A (1) and B (2) possess a rare 4,6-oxetane moiety within this compound class, and trigoheteric acid methyl ester (6) is the first example of a 15,16-dinor-3,4-seco-cleistanthane. Trigoheterin E (5) exhibited cytotoxic activity against the HL-60 (IC50 1.8 mu M) and A-549 (IC50 10.0 mu M) human cancer cell lines.

引用

页码：2576 / 2581

页数：6

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