Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma

被引：1603

作者：

Lawrie, Charles H. ^{[1
]}

Gal, Shira ^{[1
]}

Dunlop, Heather M. ^{[1
]}

Pushkaran, Beena ^{[1
]}

Liggins, Amanda P. ^{[1
]}

Pulford, Karen ^{[1
]}

Banham, Alison H. ^{[1
]}

Pezzella, Francesco ^{[1
]}

Boultwood, Jacqueline ^{[1
]}

Wainscoat, James S. ^{[1
]}

Hatton, Christian S. R. ^{[2
]}

Harris, Adrian L. ^{[3
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Lab Sci, Oxford OX3 9DU, England

[2] Univ Oxford, John Radcliffe Hosp, Dept Haematol, Oxford OX3 9DU, England

[3] Univ Oxford, Weatherall Inst Mol Med, Canc Res UK, Mol Oncol Lab, Oxford OX3 9DU, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2008年 / 141卷 / 05期

关键词：

microRNA; diffuse large B-cell lymphoma; lymphoma; sera; plasma;

D O I：

10.1111/j.1365-2141.2008.07077.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Circulating nucleic acids have been shown to have potential as non-invasive diagnostic markers in cancer. We therefore investigated whether microRNAs also have diagnostic utility by comparing levels of tumour-associated MIRN155 (miR-155), MIRN210 (miR-210) and MIRN21 (miR-21) in serum from diffuse large B-cell lymphoma (DLBCL) patients (n = 60) with healthy controls (n = 43). Levels were higher in patient than control sera (P = 0.009, 0.02 and 0.04 respectively). Moreover, high MIRN21 expression was associated with relapse-free survival (P = 0.05). This is the first description of circulating microRNAs and suggests that microRNAs have potential as non-invasive diagnostic markers for DLBCL and possibly other cancers.

引用

页码：672 / 675

页数：4

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