Significance of nuclear accumulation of Foxo3a in esophageal squamous cell carcinoma

被引：22

作者：

Chen, Miao-Fen ^{[1
]}

Fang, Fu-Min ^{[5
]}

Lu, Chang-Hsien ^{[2
]}

Lu, Ming-Shian ^{[3
]}

Chen, Wen-Cheng ^{[1
]}

Lee, Kuan-Der ^{[2
]}

Lin, Paul-Yang ^{[4
]}

机构：

[1] Chang Gung Mem Hosp, Dept Radiat Oncol, Chiayi, Taiwan

[2] Chang Gung Mem Hosp, Dept Hematol & Oncol, Chiayi, Taiwan

[3] Chang Gung Mem Hosp, Dept Thorac Surg, Chiayi, Taiwan

[4] Chang Gung Mem Hosp, Dept Pathol, Chiayi, Taiwan

[5] Chang Gung Mem Hosp, Kaohsiung Med Ctr, Dept Radiat Oncol, Kaohsiung, Taiwan

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2008年 / 71卷 / 04期

关键词：

esophageal cancer; radiation; Foxo3a;

D O I：

10.1016/j.ijrobp.2008.02.077

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Purpose: To investigate the value of Foxo3a in predicting the response to neoadjuvant treatment of, and prognosis for, esophageal squalmous cell carcinoma. Methods and Materials: Inummohistochemical staining was performed in a retrospective series of 60 biopsied esophageal squamous cell carcinomas, and the correlation between nuclear accumulation of Foxo3a and clinicopathologic features was analyzed, including patient survival. In addition, in vitro biologic changes, radiosensifivity, and in vivo tumorigenicity of esophageal carcinoma cells after experimental manipulation of Foxo3a expression levels were determined. Results: Clinical findings point to a significant correlation between the nuclear accumulation of Foxo3a and the survival rate of esophageal cancer patients. In addition, Foxo3a is a significant predictor for the response to neoadjuvant therapy. In cell culture, irradiation and oxidative stress seemed to result in nuclear accumulation of Foxo3a. Down-regulation of Foxo3a significantly decreased radiosensitivity but had no obvious effect on tumor growth, as measured by a clonogenic assay in vitro and growth delay in vivo. Conclusions: Nuclear accumulation of Foxo3a in tumor cells was correlated with increased radiosensitivity and with improved patient survival. Thus, it is suggested that Foxo3a may be a potential marker for esophageal cancer. (C) 2008 Elsevier Inc.

引用

页码：1220 / 1229

页数：10

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