Effects of diallyl sulfide and diallyl disulfide on cisplatin-induced changes in glutathione and glutathione-S-transferase activity

被引：37

作者：

Dwivedi, C

AbuGhazaleh, A

Guenther, J

机构：

[1] College of Pharmacy, Box 2202C, South Dakota State University, Brookings

来源：

ANTI-CANCER DRUGS | 1996年 / 7卷 / 07期

关键词：

cisplatin; diallyl disulfide; diallyl sulfide; glutathione; glutathione-S-transferase; nephrotoxicity;

D O I：

10.1097/00001813-199609000-00012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of diallyl sulfide (DAS) and diallyl disulfide (DADS) on cisplatin-induced changes in glutathione (GSH) and glutathione-S-transferase (GST) activity in rat liver and kidney was investigated. Cisplatin treatment significantly (p < 0.05) decreased GSH and GST activity in both river and kidney. DADS treatment significantly (p < 0.05) enhanced GSH and GST activity in rat liver and kidney. Furthermore, DADS treatment reversed the effect of cisplatin on GSH and GST activity both in liver and kidney. Administration of DADS with cisplatin could enhance GSH and GST activity and lower cisplatin-induced nephrotoxicity.

引用

页码：792 / 794

页数：3

共 12 条

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