A highly specific BODIPY-based fluorescent probe for the detection of hypochlorous acid

被引：334

作者：

Sun, Zhen-Ning ^{[1
]}

Liu, Feng-Qin ^{[2
]}

Chen, Yan ^{[2
]}

Tam, Paul Kwong Hang ^{[2
]}

Yang, Dan ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Dept Surg, Hong Kong, Hong Kong, Peoples R China

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 11期

关键词：

D O I：

10.1021/ol800507m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A fluorescent probe, HKOCl-1, has been successfully developed for the detection of hypochlorous acid on the basis of a specific reaction with p-methoxyphenol. The formation of HOCl has been successfully detected not only in an abiotic system but also in an enzymatic system (myeloperoxidase/H(2)O(2)/Cl(-) system) and in living macrophage cells upon stimulation. This new probe might be used as an efficient tool for probing the roles HOCl plays in biological systems.

引用

页码：2171 / 2174

页数：4

共 18 条

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