Human papillomavirus is a favourable prognostic factor in tonsillar cancer and its oncogenic role is supported by the expression of E6 and E7

被引：165

作者：

Lindquist, David ^{[1
]}

Romanitan, Mircea ^{[1
]}

Hammarstedt, Lalle ^{[2
]}

Naesman, Anders ^{[1
]}

Dahistrand, Hanna ^{[1
]}

Lindholm, Johan ^{[1
]}

Oneloev, Liselotte ^{[1
]}

Ramqvist, Torbjoern ^{[1
]}

Ye, Weimin ^{[3
]}

Munck-Wikland, Eva ^{[2
]}

Dalianis, Tina ^{[1
]}

机构：

[1] Karolinska Univ Hosp, Canc Ctr Karolinska, Karolinska Inst, Dept Oncol Pathol, S-17176 Stockholm, Sweden

[2] Karolinska Univ Hosp, Karolinska Inst, Dept Oto Rhino Laryngol Head & Neck Surg, S-17176 Stockholm, Sweden

[3] Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden

来源：

MOLECULAR ONCOLOGY | 2007年 / 1卷 / 03期

基金：

瑞典研究理事会;

关键词：

Human papillomavirus; Tonsillar carcinoma; Head and neck squamous; cell carcinoma; Viral load; E6; mRNA; E7;

D O I：

10.1016/j.molonc.2007.08.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

From 1970 to 2002 in the Stockholm area, we revealed a parallel three-fold increase in the incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases, indicating a possible role of HPV infection in this disease. We have now examined whether HPV and viral load in pre-treatment tonsillar cancer biopsies correlates to disease prognosis, and whether the presence of HPV-16 E6 and E7 mRNA could be ascertained. The presence of HPV-16, but not viral load, in tonsillar cancer was shown to be a favourable prognostic factor for clinical outcome. Moreover, E6 and/or E7 were expressed in almost all assessable HPV-16 positive cases, supporting an oncogenic role of HPV-16 in tonsillar cancer. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：350 / 355

页数：6

共 32 条

[31] Molecular classification identifies a subset of human papillomavirus-associated oropharyngeal cancers with favorable prognosis
Weinberger, PM
Yu, ZW
Haffty, BG
Kowalski, D
Harigopal, M
Brandsma, J
Sasaki, C
Joe, J
Camp, RL
Rimm, DL
Psyrri, A
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (05) : 736 - 747
[32] Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control
Wiest, T
Schwarz, E
Enders, C
Flechtenmacher, C
Bosch, FX
[J]. ONCOGENE, 2002, 21 (10) : 1510 - 1517

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