Mechanisms of nucleic acid translocases: lessons from structural biology and single-molecule biophysics

被引：44

作者：

Hopfner, Karl-Peter

Michaelis, Jens

机构：

[1] Gene Ctr, D-81377 Munich, Germany

[2] Dept Chem & Biochem, D-81377 Munich, Germany

[3] Univ Munich, Ctr Nanosci, D-81377 Munich, Germany

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2007年 / 17卷 / 01期

关键词：

D O I：

10.1016/j.sbi.2006.11.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Enzymes that translocate nucleic acids using ATP hydrolysis include DNA and RNA helicases, viral genome packaging motors and chromatin remodeling ATPases. Recent structural analysis, in conjunction with single-molecule studies, has revealed a wealth of new insights into how these enzymes use ATP-driven conformational changes to move on nucleic acids.

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页码：87 / 95

页数：9

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