Amniotic fluid soluble human leukocyte antigen-G in term and preterm parturition, and intra-amniotic infection/inflammation

被引：30

作者：

Kusanovic, Juan Pedro ^{[2
,4
]}

Romero, Roberto ^{[1
,2
,3
,4
]}

Jodicke, Cristiano ^{[2
,4
]}

Mazaki-Tovi, Shali ^{[2
,4
]}

Vaisbuch, Edi ^{[2
,4
]}

Erez, Offer ^{[2
,4
]}

Mittal, Pooja ^{[2
,4
]}

Gotsch, Francesca ^{[4
]}

Chaiworapongsa, Tinnakorn ^{[2
,4
]}

Edwin, Sam S. ^{[4
]}

Pacora, Percy ^{[4
]}

Hassan, Sonia S. ^{[2
,4
]}

机构：

[1] Wayne State Univ, Hutzel Womens Hosp, Perinatol Res Branch, NICHD,NIH,DHHS, Detroit, MI 48201 USA

[2] Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USA

[3] Wayne State Univ, Ctr Mol Med & Genet, Detroit, MI 48201 USA

[4] NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA

来源：

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2009年 / 22卷 / 12期

关键词：

sHLA-G; preterm labor; preterm delivery; preterm prelabor rupture of membranes; pregnancy; amniocentesis; microbial invasion of the amniotic cavity; chorioamnionitis; HLA-G EXPRESSION; FETAL INFLAMMATORY RESPONSE; NATURAL-KILLER-CELLS; CLASS-I GENE; G PROTEIN CONCENTRATIONS; NECROSIS-FACTOR-ALPHA; T-CELL; INTRAUTERINE INFECTION; PERIPHERAL-BLOOD; G POLYMORPHISMS;

D O I：

10.3109/14767050903019684

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective. Circulating soluble human leukocyte antigen-G (sHLA-G) has been associated with pregnancy complications, and determination of sHLA-G concentrations in amniotic fluid (AF) has been reported in normal pregnancies. Our aim was to determine if the AF concentrations of sHLA-G change with advancing gestation, spontaneous labor at term, and in patients with spontaneous preterm labor (PTL) with intact membranes, as well as in those with preterm prelabor rupture of membranes (PROM), in the presence or absence of intra-amniotic infection/inflammation (IAI). Study design. This cross-sectional study included the following groups: (1) mid-trimester (n = 55); (2) normal pregnancy at term with (n = 50) and without (n = 50) labor; (3) spontaneous PTL with intact membranes divided into: (a) PTL who delivered at term (n = 153); (b) PTL who delivered preterm without IAI (n = 108); and (c) PTL with IAI (n = 84); and (4) preterm PROM with (n = 46) and without (n = 44) IAI. sHLA-G concentrations were determined by ELISA. Nonparametric statistics were used for analysis. Results. (1) Among patients with PTL, the median AF sHLA-G concentration was higher in patients with IAI than in those without IAI or women that delivered at term (p<0.001 for both comparisons); (2) Similarly, patients with preterm PROM and IAI had higher median AF sHLA-G concentrations than those without IAI (p < 0.004); (3) Among patients with PTL and delivery, those with histologic chorioamnionitis and/or funisitis had a higher median AF sHLA-G concentration than those without histologic inflammation (p<0.001); and (4) The median AF sHLA-G concentration did not change with advancing gestational age. Conclusions. AF sHLA-G concentrations are elevated in preterm parturition associated to IAI as well as in histologic chorioamnionitis. We propose that sHLA-G may participate in the regulation of the host immune response against intra-amniotic infection.

引用

页码：1151 / 1166

页数：16

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