Families of H/ACA ncRNA molecules in trypanosomatids

被引：10

作者：

Doniger, Tirza ^{[1
]}

Michaeli, Shulamit ^{[1
]}

Unger, Ron ^{[1
]}

机构：

[1] Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, Ramat Gan, Israel

来源：

RNA BIOLOGY | 2009年 / 6卷 / 04期

基金：

以色列科学基金会;

关键词：

H/ACA; pseudouridylation; trypanosomes; RNA secondary structure; SMALL NUCLEOLAR RNAS; SECONDARY STRUCTURE PREDICTION; MULTIPLE SEQUENCE ALIGNMENT; GENOME-WIDE ANALYSIS; RIBOSOMAL-RNA; PSEUDOURIDINE FORMATION; NONCODING RNAS; STRUCTURAL ALIGNMENT; LEISHMANIA-MAJOR; MESSENGER-RNAS;

D O I：

10.4161/rna.6.4.9270

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

H/ACA molecules are small nucleolar RNAs (snoRNAs) that guide the conversion of a uridine into a pseudouridine. This modification is crucial for ribosomal RNA (rRNA) function. In addition, H/ACA RNA also function in ribosomal RNA processing. Unlike the double hairpin structure of H/ACA molecules in other organisms, H/ACA molecules in Trypanosomes have a single hairpin structure. Here we describe the repertoire of the 46 published H/ACA molecules in Trypanosoma brucei, as well as identify the orthologous counterparts in other Trypanosomatids enlarging the H/ACA collection in this family to over 300.

引用

收藏

页码：370 / 374

页数：5

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