Membrane-permeant esters of inositol polyphosphates, chemical syntheses and biological applications

被引：65

作者：

Li, WH

Schultz, C

Llopis, J

Tsien, RY

机构：

[1] UNIV CALIF SAN DIEGO, DEPT CHEM & BIOCHEM, LA JOLLA, CA 92093 USA

[2] UNIV CALIF SAN DIEGO, DEPT PHARMACOL, LA JOLLA, CA 92093 USA

[3] UNIV CALIF SAN DIEGO, HOWARD HUGHES MED INST, LA JOLLA, CA 92093 USA

来源：

TETRAHEDRON | 1997年 / 53卷 / 35期

关键词：

D O I：

10.1016/S0040-4020(97)00714-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Membrane-permeant derivatives of inositol polyphosphates are useful tools for biological studies. Racemic 2,3,6-tri-O-butyryl-myo-inositol 1,4,5-trisphosphate hexakis(acetoxymethyl) ester(Bt(3)IP(3)/AM), myo-inositol 1,4,5-trisphosphate hexakis(acetoxymethyl) ester (IP3/AM), hexakis(propionyloxymethyl) ester (IP3/PM) and hexakis(butyryloxymethyl) ester (IP3/BM) were therefore synthesized, Whereas extracellular application of up to 200 mu M of Bt(3)IP(3)/AM or IP3/AM to 1321N1 astrocytoma cells failed to mobilize internal calcium, IP3/PM and IP3/BM released internal calcium at concentrations as low as 20 mu M and 2 mu M, respectively. (C) 1997 Elsevier Science Ltd.

引用

页码：12017 / 12040

页数：24

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